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Molecular pathology of Lynch syndrome [PDF]
The Journal of Pathology, 2020 AbstractLynch syndrome (LS) is characterised by predisposition to colorectal, endometrial, and other cancers and is caused by inherited pathogenic variants affecting the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. It is probably the most common predisposition to cancer, having an estimated prevalence of between 1/100 and 1/180 ...
Guia Cerretelli +3 more
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Molecular pathology of lymphoma [PDF]
Eye, 2012 Ocular lymphomas can be divided into intraocular lymphomas and ocular adnexal lymphomas. The vitreoretinal lymphoma-usually a diffuse large B-cell lymphoma (DLBCL) of high-grade malignancy-is the most common lymphoid malignancy arising in the eye, while the extranodal marginal zone B-cell lymphoma (EMZL), an indolent often recurrent tumour, occurs most
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Pathology of Mouse Models of Accelerated Aging [PDF]
, 2016 Progeroid mouse models display phenotypes in multiple organ systems that suggest premature aging and resemble features of natural aging of both mice and humans.
de Bruin, A +9 more
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The molecular pathology of noroviruses [PDF]
The Journal of Pathology, 2014 AbstractNorovirus infection in humans typically results in acute gastroenteritis but may also occur in many animal species. Noroviruses are recognized as one of the most common causes of acute gastroenteritis in the world, being responsible for almost 20% of all cases.
Stephanie M, Karst +2 more
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Current opinion: where are we in our understanding and treatment of osteoarthritis?
Swiss Medical Weekly, 2016 There has been important recent progress in our understanding of the molecular pathology of osteoarthritis (OA) and how it might be treated. New technologies have been developed and others refined to identify patients for recruitment in clinical trials
Anthony Robin Poole
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Cancer Medicine, 2021 Background RNA‐sequencing‐based classifiers can stratify pancreatic ductal adenocarcinoma (PDAC) into prognostically significant subgroups but are not practical for use in clinical workflows.
Julia R. Naso +13 more
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Tissue management in precision medicine: What the pathologist needs to know in the molecular era
Frontiers in Molecular Biosciences, 2022 Precision medicine is “an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person.” Among many medical specialists involved in precision medicine, the ...
Ricella Souza da Silva +5 more
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Molecular Pathology, Diagnostics and Therapeutics: A Story of Success in 2022
, 2023 Molecular pathology, diagnostics and therapeutics are three closely related topics of critical importance in medical research and clinical practice [...
Stephen A. Bustin +1 more
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BioTechniques, 2016 RNA isolated from formalin-fixed, paraffin-embedded (FFPE) tissue is commonly evaluated in both investigative and diagnostic pathology. However, the quality of the data is directly impacted by RNA quality.
Joon-Yong Chung +2 more
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The molecular pathology of rosacea [PDF]
Journal of Dermatological Science, 2009 Rosacea is a common and chronic inflammatory skin disease that affects over 10 million Americans. Although the phenotypes of rosacea are clinically heterogeneous, they are all related by the presence of chronic facial skin inflammation. Until recently, the pathophysiology of this disease has been poorly understood and limited to descriptions of factors
Kenshi, Yamasaki, Richard L, Gallo
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