Results 41 to 50 of about 981,501 (313)

Molecular Pathology of Human Prion Diseases

, 2009
Prion diseases are fatal neurodegenerative conditions in humans and animals. In this review, we summarize the molecular background of phenotypic variability, relation of prion protein (PrP) to other proteins associated with neurodegenerative diseases ...
Herbert Budka, Gabor G. Kovacs
core   +1 more source

Case report: Pulmonary Ewing sarcoma disguised as non-small cell lung cancer

Frontiers in Oncology
Ewing sarcoma is the second most common primary malignant bone cancer in children and adolescents. This rare type of cancer is characterized by its high malignancy and therefore high risk of metastases.
Mary E. Carter, Alessia Benegiamo-Chilla, Linus D. Kloker, Nikolas Paulsen, Vlatko Potkrajcic, Frank Paulsen, Attila Nemeth, Volker Steger, Martin Schulze, Saskia Biskup, Saskia Biskup, Katrin Benzler, Stephan Singer, Ulrich M. Lauer, Ulrich M. Lauer, Ulrich M. Lauer, Lars Zender, Lars Zender, Lars Zender, Christoph K. W. Deinzer   +19 more
doaj   +1 more source

Living the best of both worlds: A personal scientific journey

FASEB BioAdvances, 2022
Opportunity is the essence of a career in science or medicine and this continues to be a major source of satisfaction for the many scientists and health care providers worldwide. Having trained as a PhD scientist, the world of clinical medicine seemed to
Gregory J. Tsongalis
doaj   +1 more source

Spotlights on adult patients with pediatric-type diffuse gliomas in accordance with the 2021 WHO classification of CNS tumors

Frontiers in Neuroscience, 2023
IntroductionThe fifth edition of the World Health Organization (WHO) classification of central nervous system (CNS) tumors released in 2021 formally defines pediatric-type diffuse gliomas.
Wenlin Chen, Shanmu Jin, Shanmu Jin, Qianshu Liu, Qianshu Liu, Hai Wang, Yu Xia, Yu Xia, Xiaopeng Guo, Xiaopeng Guo, Siying Guo, Siying Guo, Yaning Wang, Yixin Shi, Yixin Shi, Delin Liu, Delin Liu, Yilin Li, Yilin Li, Yuekun Wang, Hao Xing, Junlin Li, Junlin Li, Jiaming Wu, Jiaming Wu, Tingyu Liang, Tian Qu, Tian Qu, Huanzhang Li, Huanzhang Li, Tianrui Yang, Tianrui Yang, Kun Zhang, Kun Zhang, Yu Wang, Yu Wang, Wenbin Ma, Wenbin Ma   +37 more
doaj   +1 more source

Molecular Pathology and Biomarkers [PDF]

, 2016
The field of salivary gland tumor biology is quite broad, given the numerous subtypes of both benign and malignant tumors originating from the major and minor salivary glands. Knowledge about the molecular pathology of these lesions is still limited, and there are few clinically useful diagnostic and prognostic biomarkers.
Patrick K, Ha, Göran, Stenman
openaire   +2 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Characterization of Reference Materials with an Association for Molecular Pathology Pharmacogenetics Working Group Tier 2 Status: CYP2C9, CYP2C19, VKORC1, CYP2C Cluster Variant, and GGCX: A GeT-RM Collaborative Project

, 2021
Pharmacogenetic testing is increasingly available from clinical and research laboratories. However, only a limited number of quality control and other reference materials are currently available for many of the variants that are tested.
Turner, Amy, Broeckel, Ulrich, Medeiros, Elizabeth B., Requesens, Deborah, Pratt, Victoria M., Kalman, Lisa V., Moyer, Ann M., Vetrini, Francesco, Dawson, D. Brian, Lynnes, Ty C., Gaedigk, Andrea   +10 more
core   +1 more source

Storytelling of Myocarditis

Biomedicines
In 1900, Fiedler first reported autopsy cases with peculiar inflammation of the myocardium, which he named interstitial myocarditis. He postulated an isolated cardiac inflammation of the myocardium in the absence of multiorgan involvement and with a poor
Gaetano Thiene
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Molecular Pathogenesis of Alzheimer’s Disease: Reductionist versus Expansionist Approaches

, 2009
Alzheimer’s disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles.
George Perry, Xiongwei Zhu, Rudy J. Castellani, Mark A. Smith, Hyoung-Gon Lee   +4 more
core   +1 more source