Results 81 to 90 of about 981,501 (313)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Implementation of Novel Molecular Biomarkers for Non-small Cell Lung Cancer in the Netherlands: How to Deal With Increasing Complexity

Frontiers in Oncology, 2020
The diagnostic landscape of non-small cell lung cancer (NSCLC) is changing rapidly with the availability of novel treatments. Despite high-level healthcare in the Netherlands, not all patients with NSCLC are tested with the currently relevant predictive ...
Daan van den Broek, T. Jeroen N. Hiltermann, Bonne Biesma, Winand N. M. Dinjens, Nils A. 't Hart, John W. J. Hinrichs, John W. J. Hinrichs, Mathie P. G. Leers, Kim Monkhorst, Matthijs van Oosterhout, Volkher Scharnhorst, Ed Schuuring, Ernst-Jan M. Speel, Michel M. van den Heuvel, Ron H. N. van Schaik, Jan von der Thüsen, Stefan M. Willems, Leonie de Visser, Marjolijn J. L. Ligtenberg, Marjolijn J. L. Ligtenberg   +19 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

International Symposium of Molecular Pathology

, 2016
Office of International Symposium of Molecular Pathology (Japan-side: Kazuhisa Hasui, Kagoshima University, China-side: Xinshan Jia, China Medical ...
Office of International Symposium of Molecular Pathology (Japan-side Kazuhisa Hasui Kagoshima University China-side Xinshan Jia China Medical University), Office, of International Symposium of Molecular Pathology (Japan-side Kazuhisa Hasui Kagoshima University China-side Xinshan Jia China Medical University), 国際分子病理学シンポジウム事務局(日本側：蓮井和久、鹿児島大学、中国側：賈　心善、中国医科大学）   +2 more
core  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Translational milestones in urologic pathology: integrating molecular diagnostics across cancer types

In its first decade, The Journal of Pathology: Clinical Research has become a leading source of translational studies advancing molecular diagnostics in cancer, particularly in urologic pathology.
Acosta, Andres M., Matoso, Andres
core   +1 more source

Understanding the Role of Dysfunctional and Healthy Mitochondria in Stroke Pathology and Its Treatment [PDF]

, 2018
Stroke remains a major cause of death and disability in the United States and around the world. Solid safety and efficacy profiles of novel stroke therapeutics have been generated in the laboratory, but most failed in clinical trials. Investigations into
Napoli, Eleonora, Borlongan, Cesar V, Rajani, Mira, Sydney Zarriello, Julian Tuazon, Zarriello, Sydney, Hung Nguyen, Mira Rajani, Cesar V. Borlongan, Tuazon, Julian, Eleonora Napoli, Nguyen, Hung   +11 more
core   +1 more source

Advancing precision diagnostics: minimally invasive approaches for understanding the role of brain-limited somatic mutations in pediatric drug-resistant epilepsy

Frontiers in Surgery
For the one-third of epilepsy patients whose disease is refractory to medical therapies, the social, economic, and developmental consequences are often devastating and lifelong. This has sparked great interest in the elucidation of the genetic drivers of
Olubunmi A. Fariyike, Olubunmi A. Fariyike, Nishanth Narayan, Hilary Y. Liu, Danielle R. Sanchez, Danielle R. Sanchez, H. Westley Phillips   +6 more
doaj   +1 more source

Quality Assessment Across Disciplines in Head and Neck Cancer Treatment Diagnostic Pathology in HNSCC

Frontiers in Oncology, 2020
Quality assured pathology services are integral to provision of optimal management for patients with head and neck cancer. Pathology services vary globally and are dependent on resources in terms of both laboratory provision and availability of a highly ...
Philip Sloan, Max Robinson
doaj   +1 more source