Results 71 to 80 of about 981,501 (313)

Report From the International Society of Urological Pathology (ISUP) Consultation Conference On Molecular Pathology Of Urogenital Cancers. II. Molecular Pathology of Bladder Cancer: Progress and Challenges

, 2020
During the 2019 International Society of Urological Pathology Consultation Conference on Molecular Pathology of Urogenital Cancer, the Working Group on Bladder Cancer presented the current status and made recommendations on the diagnostic use of ...
van, der Kwast T, Egevad, L, Liang Cheng, Yves, A, Joshua I. Warrick, Glen Kristiansen, Kristiansen, G, David J. Grignon, van der Kwast, T, Allory Yves, Hartmann, A, Margaret A. Knowles, Egevad, L,, Cheng, L, Theo van der Kwast, Warrick, JI, Grignon, DJ, Lars Egevad, Arndt Hartmann, Knowles, MA   +19 more
core   +1 more source

GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process

, 2023
G protein-coupled receptors (GPCRs) play a significant role in controlling biological paradigms such as aging and aging-related disease. We have previously identified receptor signaling systems that are specifically associated with controlling molecular ...
İrem Harputluoğlu, Claudia Schrauwen, Stuart Maudsley, Hanne Leysen, Deborah Walter, Patricia McDonald   +5 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

ISSVA Classification of Vascular Anomalies and Molecular Biology

, 2022
Vascular anomalies include various diseases, which are classified into two types according to the International Society for the Study of Vascular Anomalies (ISSVA) classification: vascular tumors with proliferative changes of endothelial cells, and ...
Kayo Kunimoto, Yuki Yamamoto, Masatoshi Jinnin   +2 more
core   +1 more source

How can the postgraduate training program in pathology departments in India be improved?

Indian Journal of Pathology and Microbiology, 2011
There exists a wide variation in the competence of the postgraduate residents trained in pathology in different institutions across India. This results in strong disparities in the clinical diagnostic skills, teaching skills, research capabilities and ...
Shivayogi R Bhusnurmath, Bharti S Bhusnurmath   +1 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers. I. Molecular Biomarkers in Prostate Cancer. [PDF]

, 2020
The combined clinical and molecular heterogeneity of prostate cancer necessitates the use of prognostic, predictive, and diagnostic biomarkers to assist the clinician with treatment selection.
Tamara L. Lotan, Scott A. Tomlins, Egevad, Lars, Tarek A. Bismar, Glen Kristiansen, Bubendorf, Lukas, Kristiansen, Glen, Van der Kwast, Theodorus H, Grignon, David, Lukas Bubendorf, Rubin, Mark A, Bismar, Tarek A, Lotan, Tamara L, Mark A. Rubin, Pritchard, Colin C, Theodorus H. Van der Kwast, Lars Egevad, David Grignon, Colin C. Pritchard, Tomlins, Scott A   +19 more
core   +1 more source

Major Tumor Suppressor and Oncogenic Non-Coding RNAs: Clinical Relevance in Lung Cancer

Cells, 2017
Lung cancer is the leading cause of cancer deaths worldwide, yet there remains a lack of specific and sensitive tools for early diagnosis and targeted therapies.
Kentaro Inamura
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source