Results 91 to 100 of about 363,849 (261)

Molecular Pharmacology of Inflammation Resolution in Atherosclerosis. [PDF]

Int J Mol Sci, 2022
Kotlyarov S, Kotlyarova A.
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

A SWELL time to develop the molecular pharmacology of the volume-regulated anion channel (VRAC). [PDF]

Channels (Austin), 2022
Figueroa EE, Denton JS.
europepmc   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Editorial: New GPCR targets and modulators to treat CNS disorders

Frontiers in Molecular Neuroscience, 2022
Philippe De Deurwaerdère, Evgeni Ponimaskin, Abdeslam Chagraoui, Abdeslam Chagraoui, Giuseppe Di Giovanni, Giuseppe Di Giovanni   +5 more
doaj   +1 more source

The potential mechanism of ursolic acid in the treatment of bladder cancer based on network pharmacology and molecular docking

Journal of International Medical Research
Objective This study explored the potential molecular mechanisms of ursolic acid (UA) in bladder cancer treatment using network pharmacology and molecular docking.
Xiao-Long Huang, Yan Sun, Peng Wen, Jun-Cheng Pan, Wei-Yang He   +4 more
doaj   +1 more source

Deciphering the anti-atherosclerotic mechanisms of Danggui-Chuanxiong herb pair: a synergistic approach combining computational prediction and in vivo verification

Frontiers in Cardiovascular Medicine
IntroductionDanggui-Chuanxiong is a classic Chinese medicine formulation clinically employed for atherosclerosis (AS) management by modulating lipid metabolism and improving hemodynamic properties.Materials and methodsIntegrated network pharmacology ...
Yuemeng Sun, Yixing Lu, Fei Ge, Hao Wu, Zhanhong Qian, Jianbei Chen, Jianbei Chen, Hua Hao   +7 more
doaj   +1 more source

Computation and molecular pharmacology to trace the anti-rheumatoid activity of Angelicae Pubescentis Radix. [PDF]

BMC Complement Med Ther, 2022
Zhang J, Wang R, Liang X, Bai HT, Li YL, Sun S, Zhang Q, Yang J.   +7 more
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source