Results 201 to 210 of about 363,849 (261)

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, EarlyView.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Development of Artificial Sebaceous Gland‐Integrated In Vitro Human Skin Model

Advanced Materials Interfaces, EarlyView.
Uniform 3D artificial sebaceous gland spheroids, termed SebaSpheres, are generated at high throughput using a microfluidic platform and structurally integrated into a collagen‐based skin construct containing fibroblasts and keratinocytes. This work presents a modular and scalable fabrication and integration strategy for incorporating sebaceous gland ...
Daeun Ryu, Hyewon Noh, Jimin Son, Haejung Lee, Bo Mi Kang, Chong Won Choi, Jong Hwan Sung, Jae Jung Kim   +7 more
wiley   +1 more source

BLOC: Buildable and Linkable Organ on a Chip

Advanced Materials Technologies, EarlyView.
We developed a “Buildable and Linkable Organ on a Chip” (BLOC) that can construct diverse microphysiological systems (MPSs). The BLOC is standardized to the same size and has one of the functions of “Culture,” “Control,” or “Analysis.” Users can freely configure various MPSs, including developing perfusion, cytotoxicity analysis, and biochemical ...
Yusuke Kimura, Hiroki Hamaguchi, Kotaro Oyama, Tomoko G. Oyama, Atsushi Kimura, Yasuhiro Ohshima, Noriko S. Ishioka, Mitsumasa Taguchi   +7 more
wiley   +1 more source

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Molecular pharmacology of niaprazine

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1988
1. The pharmacological profile of niaprazine was investigated using in vitro ligand binding techniques. 2. Niaprazine exhibits a low affinity for the vesicular monoamine transporter and for D2, alpha 2, beta, H1 and muscarinic cholinergic receptors. Niaprazine, particularly the (+)stereoisomer, has a higher affinity for alpha 1 (Ki = 77 nM) and 5-HT2 ...
D, Scherman, M, Hamon, H, Gozlan, J P, Henry, A, Lesage, M, Masson, J F, Rumigny   +6 more
openaire   +2 more sources

Molecular Pharmacology of Gonadotropins

Endocrine, 2005
Gonadotropins have been studied in biological systems for decades and many of their properties are well defined. These include pharmacological properties such as affinity, stability, and pharmacokinetics also used to characterize drugs. Technologies applied to research on gonadotropins have led to the creation of hormone analogs with alterations to one
openaire   +2 more sources

Molecular Pharmacology of Phytocannabinoids

2017
Cannabis sativa has been used for recreational, therapeutic and other uses for thousands of years. The plant contains more than 120 C21 terpenophenolic constituents named phytocannabinoids. The Δ9-tetrahydrocannabinol type class of phytocannabinoids comprises the largest proportion of the phytocannabinoid content.
Sarah E, Turner, Claire M, Williams, Leslie, Iversen, Benjamin J, Whalley   +3 more
openaire   +2 more sources

Molecular Pharmacology of Hallucinogens

1968
There is as yet no satisfactory biological explanation for any of the major psychoses. However, the gap in knowledge is diminishing, and already there is a flourishing exchange of ideas and correlations between clinician and researcher. In fact, there is an ever increasing number of practising psychiatrists with active biological research interests.
V S, Johnston, R J, Bradley
openaire   +2 more sources

Molecular pharmacology of somatostatin receptors

Naunyn-Schmiedeberg's Archives of Pharmacology, 1994
The neuropeptide somatostatin (SRIF) is widely expressed in the brain and in the periphery in two main forms, SRIF-14 and SRIF-28. Similarly, the presence of SRIF receptors throughout the whole body has been reported. SRIF produces a variety of effects including modulation of hormone release (e.g.
D, Hoyer, H, Lübbert, C, Bruns
openaire   +2 more sources

Molecular Pharmacology of Nitrosoureas

1981
The development of a wide range of aliphatic nitrosamides has followed the original observation that l-methyl-l-nitroso-3-nitrosoguanidine had reproducible antitumor activity against murine L1210 leukemia [7]. The resultant synthesis of new N-nitroso containing compounds has produced two general classes of drug, the methyl and chloroethyl nitrosoureas.
K D, Tew, M E, Smulson, P S, Schein
openaire   +2 more sources

Molecular pharmacology of somatostatin receptors

Fundamental & Clinical Pharmacology, 1995
Summary—Somatostatin was discovered for its ability to inhibit growth hormone (GH) secretion. Later, it was found to be widely distributed in other brain regions, in which it fulfills a neuromodulatory role, and in several organs of the gastrointestinal tract where it can act as a paracrine factor or as a true circulating factor.
C, Viollet, G, Prévost, E, Maubert, A, Faivre-Bauman, R, Gardette, C, Kordon, C, Loudes, A, Slama, J, Epelbaum   +8 more
openaire   +2 more sources