Results 211 to 220 of about 363,849 (261)
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Molecular pharmacology of P2Y-receptors
Naunyn-Schmiedeberg's Archives of Pharmacology, 2000Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong to the superfamily of G-protein-coupled receptors. So far, the P2Y family is composed of eight cloned and functionally defined subtypes.
I, von Kügelgen, A, Wetter
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Molecular targets for pharmacological cytoprotection
Biochemical Pharmacology, 2001Cell death is common to many pathological conditions. In the past two decades, research into the mechanism of cell death has characterized the cardinal features of apoptosis and necrosis, the two distinct forms of cell death. Studies using in vivo disease models have provided evidence that apoptosis is induced by an array of pathological stimuli. Thus,
A, Balla +4 more
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Molecular pharmacology of protein kinases
Neurochemical Research, 1990Apercu des differents inhibiteurs et des activateurs de plusieurs proteines kinases etudies par les auteurs, leurs approches biochimiques et pharmacologiques et leurs applications cliniques ...
H, Hidaka, M, Hagiwara, T, Chijiwa
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Pharmacologic Vitreodynamics and Molecular Flux
2009Several enzymatic agents, such as autologous plasmin enzyme and recombinant microplasmin, are able to cause vitreous liquefaction and a complete posterior vitreous detachment (PVD). Advancements in research have helped to explain the complex interactions that occur in the vitreous cavity after a PVD is created.
David T, Goldenberg, Michael T, Trese
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Let′s ′play′ with molecular pharmacology
Education for Health, 2015Understanding concepts of molecular mechanisms of drug action involves sequential visualization of physiological processes and drug effects, a task that can be difficult at an undergraduate level. Role-play is a teaching-learning methodology whereby active participation of students as well as clear visualization of the phenomenon is used to convey ...
Supriyo, Choudhury +6 more
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The Molecular Pharmacology of SERMs
Trends in Endocrinology & Metabolism, 1999Estrogen-containing medicines have been used successfully for the past 50 years for the treatment of conditions associated with menopause. Although initially considered a reproductive hormone, millions of years of clinical exposure to estrogen(s) have indicated that its influence extends to a variety of target tissues not generally considered to be ...
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Molecular Pharmacology of β-Adrenoceptors
Journal of Cardiovascular Pharmacology, 1986The development of radioligand-binding studies has greatly advanced our knowledge of the molecular pharmacology of beta-adrenoceptors. With this technique it is possible for the first time to directly determine the tissue concentration of beta-adrenoceptors, and by this, the responsiveness of tissues to beta-adrenergic stimulation.
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Molecular biology of pharmacologic vitreolysis
American Journal of Ophthalmology, 2006Pharmacologic vitreolysis is a promising new therapy to improve vitreoretinal surgery and, ultimately, prevent disease by mitigating the contribution of vitreous to retinopathy. The mechanism of action of the agents being developed for pharmacologic vitreolysis remains unclear.
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The promises and perils of psychedelic pharmacology for psychiatry
Nature Reviews Drug Discovery, 2022Bryan L Roth
exaly
Emerging principles of cytokine pharmacology and therapeutics
Nature Reviews Drug Discovery, 2022, Caleb R Glassman, K Christopher Garcia
exaly