Results 171 to 180 of about 1,727,695 (209)

Molecular Phenotyping With Proteomics

JAMA
This JAMA Insights explores the capability of proteomics to analyze thousands of proteins in patient samples, which could improve clinicians’ understanding of and ability to treat a wide range of diseases.
Devin K, Schweppe, Brian J, Beliveau, Andrew N, Hoofnagle   +2 more
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The Osteoclast Molecular Phenotype

1998
Publisher Summary This chapter discusses the osteoclast molecular phenotype. Several new cell purification and molecular biology techniques have been applied to the study of osteoclasts that have made possible more sensitive and quantitative analysis of osteoclast gene expression.
Dennis Sakai, Cedric Minkin
openaire   +1 more source

Airway molecular phenotypes in pediatric asthma

Current Opinion in Allergy & Clinical Immunology, 2011
The review discusses what is known regarding airway molecular phenotypes in pediatric asthma, specifically biomarkers that have been studied and their relation to the various clinical phenotypes of asthma.Pediatric asthma is a complex and heterogeneous disease that consists of several clinical phenotypes.
Shean J, Aujla, Kristie R, Ross, James F, Chmiel, Fernando, Holguin   +3 more
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Molecular aspects of the epithelial phenotype

BioEssays, 1997
AbstractEpithelia can be defined morphologically as tissues that line surfaces, and ultrastructurally with reference to their cells' apico‐basal polarity and possession of specific cell‐cell junctions. Defining the epithelial phenotype at a molecular level is more problematic ‐ while it is easy to name proteins (e.g.
J A, Davies, D R, Garrod
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Molecular biology of partial D phenotypes

Transfusion Clinique et Biologique, 1996
We have examined all DVI variant phenotypes submitted to the workshop by a combination of RT-PCR, multiplex RHD PCR and immunoblotting with Rh antipeptide sera. Our findings suggest that all DVI phenotypes arise through hybrid RHD-RHCE-RHD genes. Genomic DNA derived from all DVI samples were shown to be RHD intron 4 negative when analysed with an RHD ...
N D, Avent, K M, Finning, W, Liu, M L, Scott   +3 more
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Endotoxemic Shock: A Molecular Phenotype in Sepsis

Nephron, 2022
Background: Marked heterogeneity exists among patients with sepsis, both in terms of distribution of organ dysfunction and its severity. Such heterogeneity could be explained by the presence of multiple subtypes of sepsis that may have important implications for treatment.
John A, Kellum, Debra, Foster, Paul M, Walker   +2 more
openaire   +2 more sources

Molecular phenotypes of colorectal cancer.

Journal of Clinical Oncology, 2022
e15506 Background: Despite the positive results of colorectal cancer treatment, there is a group of patients that progresses despite successful treatment for I–II stage of the disease. it may be that modern predictors in do not fully cover the entire spectrum of molecular genetic traits, especially the tumor microenvironment.
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Genotype, molecular phenotype, and cognitive phenotype: Correlations in fragile X syndrome

American Journal of Medical Genetics, 1999
The study of the neurobehavioral consequences of mutations of FMR1, the gene responsible for fragile X syndrome (FraX), has been based largely on correlations between mutation patterns and cognitive profile. Following the characterization of FMRP, the FMR1 gene product, preliminary correlations between FMRP levels, and neurologic phenotype have been ...
W E, Kaufmann, M T, Abrams, W, Chen, A L, Reiss   +3 more
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Osteoclast molecular phenotyping by random cDNA sequencing

Bone, 1995
The osteoclast is a cell type that is highly specialized for its bone resorption function. In order to decipher the numerous biochemical functions of osteoclasts, a description of the gene expression profile of osteoclasts would be beneficial. We have sought to identify genes that are highly expressed in osteoclasts by partially sequencing 194 randomly
D, Sakai, H S, Tong, C, Minkin
openaire   +2 more sources

Molecular phenotype of airway side population cells

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2004
Lung epithelial-specific stem cells have been localized to discrete microenvironments throughout the adult conducting airway. Properties of these cells include pollutant resistance, multipotent differentiation, and infrequent proliferation. Goals of the present study were to use Hoechst 33342 efflux, a property of stem cells in other tissues, to purify
Adam, Giangreco, Hongmei, Shen, Susan D, Reynolds, Barry R, Stripp   +3 more
openaire   +2 more sources