Results 61 to 70 of about 1,727,695 (209)

Plant Proteases: From Phenotypes to Molecular Mechanisms [PDF]

Annual Review of Plant Biology, 2008
Plant genomes encode hundreds of proteases, which represent dozens of unrelated families. The biological role of these proteases is mostly unknown, but mutant alleles, gene silencing, and overexpression studies have provided phenotypes for a growing number of proteases. The aim of this review is to show the diversity of the processes that are regulated
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Clinical and Molecular Phenotype of Aicardi-Goutières Syndrome [PDF]

The American Journal of Human Genetics, 2007
Aicardi-Goutieres syndrome (AGS) is a genetic encephalopathy whose clinical features mimic those of acquired in utero viral infection. AGS exhibits locus heterogeneity, with mutations identified in genes encoding the 3'-->5' exonuclease TREX1 and the three subunits of the RNASEH2 endonuclease complex.
Rice, Gillian, Patrick, Teresa, Parmar, Rekha, Taylor, Claire F., Aeby, Alec, Aicardi, Jean, Artuch, Rafael, Montalto, Simon Attard, Bacino, Carlos A., Barroso, Bruno, Baxter, Peter, Benko, Willam S., Bergmann, Carsten, Bertini, Enrico, Biancheri, Roberta, Blair, Edward M., Blau, Nenad, Bonthron, David T., Briggs, Tracy, Brueton, Louise A., Brunner, Han G., Burke, Christopher J., Carr, Ian M., Carvalho, Daniel R., Chandler, Kate E., Christen, Hans-Jurgen, Corry, Peter C., Cowan, Frances M., Cox, Helen, D'Arrigo, Stefano, Dean, John, de Laet, Corinne, de Praeter, Claudine, Dery, Catherine, Ferrie, Colin D., Flintoff, Kim, Frints, Suzanna G. M., Garcia-Cazorla, Angels, Gener, Blanca, Goizet, Cyril, Goutieres, Francoise, Green, Andrew J., Guet, Agnes, Hamel, Ben C. J., Hayward, Bruce E., Heiberg, Arvid, Hennekam, Raoul C., Husson, Marie, Jackson, Andrew P., Jayatunga, Rasieka, Jiang, Yong-Hui, Kant, Sarina G., Kao, Amy, King, Mary D., Kingston, Helen M., Klepper, Joerg, van der Knaap, Marjo S., Kornberg, Andrew J., Kotzot, Dieter, Kratzer, Wilfried, Lacombe, Didier, Lagae, Lieven, Landrieu, Pierre Georges, Lanzi, Giovanni, Leitch, Andrea, Lim, Ming J., Livingston, John H., Lourenco, Charles M., Lyall, E. G. Hermione, Lynch, Sally A., Lyons, Michael J., Marom, Daphna, McClure, John P., McWilliam, Robert, Melancon, Serge B., Mewasingh, Leena D., Moutard, Marie-Laure, Nischal, Ken K., Ostergaard, John R., Prendiville, Julie, Rasmussen, Magnhild, Rogers, R. Curtis, Roland, Dominique, Rosser, Elisabeth M., Rostasy, Kevin, Roubertie, Agathe, Sanchis, Amparo, Schiffmann, Raphael, Scholl-Burgi, Sabine, Seal, Sunita, Shalev, Stavit A., Corcoles, C. Sierra, Sinha, Gyan P., Soler, Doriette, Spiegel, Ronen, Stephenson, John B. P., Tacke, Uta, Tan, Tiong Yang, Till, Marianne, Tolmie, John L., Tomlin, Pam, Vagnarelli, Federica, Valente, Enza Maria, van Coster, Rudy N. A., van der Aa, Nathalie, Vanderver, Adeline, Vles, Johannes S. H., Voit, Thomas, Wassmer, Evangeline, Weschke, Bernhard, Whiteford, Margo L., Willemsen, Michel A. A., Zankl, Andreas, Zuberi, Sameer M., Orcesi, Simona, Fazzi, Elisa, Lebon, Pierre, Crow, Yanick J., Østergaard, John R., Tiong, Yang Tan   +119 more
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APPROACHES TO ANALYSIS OF GENOTYPE AND PHENOTYPE RELATION WITH QTL METHODS [PDF]

Научно-технический вестник информационных технологий, механики и оптики, 2018
The paper describes methods of QTL-analysis in the research of the genotype influence. QTL-analysis is a statistical method that connects phenotypic data with genotype, enables the determination of the exact localization and gene influence power. The QTL
Furta E.Yu., Shabalina I.M.
doaj   +1 more source

Treatment response assessment with (R)-[11CPAQ PET in the MMTV-PyMT mouse model of breast cancer

EJNMMI Research, 2018
Background The goal of the study was to assess the potential of the vascular endothelial growth factor receptor (VEGFR)-2-targeting carbon-11 labeled (R)-N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-3-piperidinyl)methoxy)-4-quinazolineamine ((R ...
T. Tegnebratt, L. Lu, S. Eksborg, A. Chireh, P. Damberg, S. Nikkhou-Aski, T. Foukakis, H. Rundqvist, S. Holmin, R. V. Kuiper, E. Samen   +10 more
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The intriguing occurrence of Acute Myeloid Leukemia in a case of Acute Lymphoblastic leukemia:Report of two cases

Journal of Applied Hematology, 2020
The aim of this study is to study the two cases of acute lymphoblastic leukemia (ALL) who relapsed as acute myeloid leukemia (AML). Presented here are reports of two cases of pediatric ALL who developed change of lineage to AML at relapse. This change in
Manasi Chetan Mundada, Faiq Ahmed, Mohan Krishna Pasam, Sudha Murthy, A Santa, Veerendra Patil   +5 more
doaj   +1 more source

Molecular analysis and phenotype characterization of the progeny of two antisense potato plants [PDF]

, 2008
Two transgenic potato lines csr2-1 and csr4-8, containing two different antisense constructs, csr2 and csr4, respectively, were crossed to investigate the possibility of achieving double transformants with combined effects of the two antisense transgenes
Jacobsen, E., Olawole, O., Visser, R.G.F.   +2 more
core   +1 more source

Large-scale albuminuria screen for nephropathy models in chemically induced mouse mutants [PDF]

, 2005
Background/Aim: Phenotype-driven screening of a great pool of randomly mutant mice and subsequent selection of animals showing symptoms equivalent to human kidney diseases may result in the generation of novel suitable models for the study of the ...
Aigner, B., de Angelis, M. H., Klempt, M., Rathkolb, B., Tran, T. V., Wanke, R., Wolf, E.   +6 more
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Molecular Basis of KELnull Phenotype in Brazilians [PDF]

Transfusion Medicine and Hemotherapy, 2014
<b><i>Background:</i></b> KELnull (K&#8320;) persons can produce clinically significant anti-KEL5 antibody after transfusion and/or pregnancy, requiring K&#8320; blood transfusion when indicated. 37 K&#8320; alleles have been reported in studies over different populations, but none in Amerindian-Caucasian descendants
Edmir, Boturão-Neto, Mihoko, Yamamoto, Akemi Kuroda, Chiba, Elisa Yuriko Sugano, Kimura, Maria do Carmo Valgueiro Costa, de Oliveira, Cláudia Lumack, do Monte Barretto, Mércia Maria Alves, Nunes, Sérgio Roberto Lopes, Albuquerque, Marcos Daniel, de Deus Santos, José Orlando, Bordin   +9 more
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Molecular Clustering of Metabolic Dysfunction-Associated Steatotic Liver Disease Based on Transcriptome Analysis

Diagnostics
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex metabolic disorder with a diverse spectrum. This study aimed to classify patients with MASLD into molecular subtypes based on the underlying pathophysiology ...
Gina Ryu, Eileen Laurel Yoon, Wankyu Kim, Dae Won Jun   +3 more
doaj   +1 more source

Kinesin Light Chains Are Essential for Axonal Transport in Drosophila [PDF]

, 1998
Kinesin is a heterotetramer composed of two 115-kD heavy chains and two 58-kD light chains. The microtubule motor activity of kinesin is performed by the heavy chains, but the functions of the light chains are poorly understood.
Beushausen, Sven, Desai, Chand J., Gindhart, Joseph G., Jr., Goldstein, Lawrence S. B., Zinn, Kai   +4 more
core   +2 more sources