Results 141 to 150 of about 279,526 (309)

Cytogenomic assessment of the diagnosis of 93 patients with developmental delay and multiple congenital abnormalities: The Brazilian experience

Clinics
OBJECTIVE: The human genome contains several types of variations, such as copy number variations, that can generate specific clinical abnormalities.
Évelin Aline Zanardo, Roberta Lelis Dutra, Flavia Balbo Piazzon, Alexandre Torchio Dias, Gil Monteiro Novo-Filho, Amom Mendes Nascimento, Marília Moreira Montenegro, Jullian Gabriel Damasceno, Fabrícia Andreia Rosa Madia, Thaís Virgínia Moura Machado da Costa, Maria Isabel Melaragno, Chong Ae Kim, Leslie Domenici Kulikowski   +12 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Atom Probe Tomography of Molecular Organic Materials: Sub-Dalton Nanometer-Scale Quantification

, 2019
In this paper, we demonstrate that atom probe tomography (APT) can be applied to small-molecule organic materials. We show that APT can provide an unprecedented combination of mass resolution of
Jeramy D. Zimmerman (1895923), Matthew B. Jaskot (3105387), Andrew P. Proudian, Andrew P. Proudian (3105384), Jeramy D. Zimmerman, Matthew B. Jaskot, David R. Diercks, Brian P. Gorman, Brian P. Gorman (1538710), David R. Diercks (1538713)   +9 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

CHARACTERIZING MOLECULAR IONS FOR LASER CONTROL

Variation of fundamental constants would indicate physics beyond the Standard Model. Astronomical evidence and proposed theoretical models suggest a possible variation in the proton to electron mass ratio ($\mu$).
Venkataramanababu, Sruthi
core   +1 more source

In situ hybridization to detect bandicoot papillomatosis carcinomatosis virus type 1 in biopsies from endangered western barred bandicoots (Perameles bougainville)

, 2008
The western barred bandicoot (Perameles bougainville) is an endangered Australian marsupial species in which a papillomatosis and carcinomatosis syndrome occurs.
Bennett, M., Nicholls, Philip K., Warren, K., Warren, Kristin S., Bennett, M.D., Bennett, Mark D., Woolford, L., Nicholls, P., Woolford, Lucy, O'Hara, Amanda J., Nicholls, P.K., Warren, K.S., O'Hara, A., O'Hara, A.J.   +13 more
core   +1 more source

The determination of the crystallinity of polyolefins by the technique of molecular probe

Polimery, 1981
ANDRZEJ WLOCHOWICZ, BARBARA JURCZAK, ZOFIA ZAK   +2 more
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The value of fluorescence and B22 techniques as complementary approaches in protein stability analyses [PDF]

, 2011
Recombinant proteins gain more and more importance in the pharmaceutical market. One major challenge is to assure the protein integrity during manufacturing, shipping and storage.
Printz, Miriam
core  

Ribotyping, biotyping and capsular typing of Haemophilus influenzae strains isolated from patients in Campinas, southeast Brazil

Brazilian Journal of Infectious Diseases
Forty-five Haemophilus influenzae strains isolated from patients were characterized based on biochemical characteristics. Their capsular types were determined by polymerase chain reaction (PCR); they were compared, using two molecular methods [ribotyping
Marcelo Lancellotti, Fernanda de Pace, Eliana Guedes Stehling, Maria Cecília Barisson Villares, Marcelo Brocchi, Wanderley Dias da Silveira   +5 more
doaj   +1 more source