Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular structure of agarose chains in thermoreversible hydrogels revealed by means of a fluorescent probe technique [PDF]
, 2005 Hideyuki Itagaki +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Beyond resolution: AI-powered subcellular bioimaging for next-generation smart diagnostics
Biosensors and Bioelectronics: XThe dynamic landscape of subcellular imaging is entering a transformative era fueled by synergistic advances in fluorescent probe design and artificial intelligence (AI).
Andrés F. Luis-Robles +2 more
doaj +1 more source
N-fluoroacetyl-α-
, 1971 P. W. Kent, Raymond A. Dwek
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Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Chemical modification of 2D materials using molecules and assemblies of molecules
Advances in Physics: X, 2019 In this article, we discuss the recent progress on controlled structural modification of 2D materials by means of molecular functionalization, with a focus on scanning probe microscopy techniques for their characterization.
Lakshya Daukiya +2 more
doaj +1 more source
Probe into Mechanism of Treatment of Ulcerative Colitis by Using Network Pharmacology and Molecular Docking Techniques [PDF]
, 2022 openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source