Results 131 to 140 of about 279,526 (309)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Identification of pathogenic Leptospira by TaqMan probe in a LightCycler
, 1998 The genus Leptospira is divided into two species of which Leptospira interrogans is an animal pathogen which causes infections in humans when in contact with body fluids of infected animals, whereas Leptospira biflexa is a nonpathogenic saprophyte ...
Patel, B. K. C. +5 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Bringing to light transient molecular structure and function using advanced vibrational spectroscopy [PDF]
, 2019 As chemical synthetic methods have developed so has the complexity and functionality of synthesised compounds. In order to investigate their structure and function, especially when the function results from a perturbation, more sophisticated ...
Strudwick, B.H.
core
Beyond resolution: AI-powered subcellular bioimaging for next-generation smart diagnostics
Biosensors and Bioelectronics: XThe dynamic landscape of subcellular imaging is entering a transformative era fueled by synergistic advances in fluorescent probe design and artificial intelligence (AI).
Andrés F. Luis-Robles +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Chemical modification of 2D materials using molecules and assemblies of molecules
Advances in Physics: X, 2019 In this article, we discuss the recent progress on controlled structural modification of 2D materials by means of molecular functionalization, with a focus on scanning probe microscopy techniques for their characterization.
Lakshya Daukiya +2 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2008 Molecular techniques have clear value for community characterization; however, almost all previous datasets are based upon non-molecular measurements and it is hard to compare "old" data with "new" data because few correlations have been made. Therefore,
Findlay, David L +3 more
core +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source