Results 111 to 120 of about 279,526 (309)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Gold nanorods as molecular probes for light-based imaging techniques [PDF]

, 2010
The thesis describes the use of gold nanorods as molecular probes for light-based imaging techniques for potential applications in biology and medicine. An overview of the synthesis and critical parameters influencing the synthesis of gold nanorods on size/shape/yield of nanorods are discussed. For using gold nanorods in vivo, the concerns of toxicity,
openaire   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Estudo de processos fotofísicos de sondas fluorescentes em meio aquoso e micelar com surfactantes dipolares iônicos [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2013.As características espectrais e intensidades de fluorescência de sondas determinadas em ...
Pedro, Jorge Alberto
core  

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Molecular psychiatry of zebrafish

, 2014
Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry.
Parker, M. O., Stewart, AM, Stewart, A. M., Stewart, A. M ., Ullmann, J. F. P., Norton, WHJ, Ullmann, JFP, Kalueff, A. V., Gerlai, R, Norton, W. H. J., Brennan, C. H., Gerlai, R., Brennan, CH, Parker, MO, Kalueff, AV   +14 more
core   +1 more source

Improvement of a method for the characterization of ultrafiltration membranes by measurements of tracers retention [PDF]

, 2004
The aim of this study is to improve protocols for assessing accurate characteristic retention curve and cut-off of membranes, thus enabling the manufacture and performance of the membrane to be monitored. Different data treatments are considered in order
Causserand, Christel, Aimar, Pierre, Rouaix, Sandrine, Akbari, Ahmad   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A Novel Type of Dual-Modality Molecular Probe for MR and Nuclear Imaging of Tumor: Preparation, Characterization and in Vivo Application

, 2016
A novel dual-modality molecular probe composed of biocompatible Fe3O4 nanocrystal, monoclonal antibody and radionuclide was designed and prepared. All functional components in the dual-modality molecular probe, i.e., Fe3O4, PEG, mAb 3H11 and 125I, were ...
Fan Wang (135182), Zilin Yu (2214664), Zhaofei Liu (1583062), Jiyun Shi (1515901), Kan Liu (250462), Ruirui Qiao (1651222), Han Ouyang (709961), Zhi Yang (124104), Mingyuan Gao (1406650), Shujie Liu (677776), Bing Jia (460031)   +10 more
core   +1 more source