Results 91 to 100 of about 654,387 (333)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Chemoproteomics, A Broad Avenue to Target Deconvolution

Advanced Science
As a vital project of forward chemical genetic research, target deconvolution aims to identify the molecular targets of an active hit compound.
Yihui Gao, Mingzhe Ma, Wenyang Li, Xiaoguang Lei   +3 more
doaj   +1 more source

Ramanomics: New Omics Disciplines Using Micro Raman Spectrometry with Biomolecular Component Analysis for Molecular Profiling of Biological Structures

Biosensors, 2017
Modern instrumentation for Raman microspectroscopy and current techniques in analysis of spectral data provide new opportunities to study molecular interactions and dynamics at subcellular levels in biological systems.
Andrey N. Kuzmin, Artem Pliss, Paras N. Prasad   +2 more
doaj   +1 more source

Optical Molecular Imaging in the Gastrointestinal Tract [PDF]

, 2013
Recent developments in optical molecular imaging allow for real-time identification of morphological and biochemical changes in tissue associated with gastrointestinal neoplasia.
American Cancer Society, American Cancer Society, American Cancer Society, Bedard, Behrens, Bird-Lieberman, Brown, Curvers, Curvers, Drexler, Dunbar, Enzinger, Gaddam, Goetz, Goetz, Graf, Hsiung, Iftimia, Ishimura, Jayasekera, Jennifer Carns, Kahi, Kara, Kara, Miller, Monici, Muldoon, Muldoon, Muto, Pasha, Pelham Keahey, Rebecca Richards-Kortum, Reid, Ries, Robles, Shahid, Shahid, Sharma, Sharma, Sharma, Sharmila Anandasabapathy, Singh, Singh, Terry, Thekkek, Timothy Quang, Vieth, Wallace, Wang, Wang, Wang, Wax, Winkler, Yang, Yuan, Zhou, Zhu   +56 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Sex Identification of Newly Hatched Chicks by Fluorescence in situ Hybridization using a W-specific DNA Probe in Feather Follicle Cells

The Journal of Poultry Science, 2012
The identification of the sex of chickens or chicken cells has biological and industrial significance. In the laboratory, molecular techniques have utilized W chromosome-specific repetitive DNA sequence fragments, such as Xho I or EcoR I family, for ...
Sea H. Sohn, Eun J. Cho, Bo S. Kang
doaj   +1 more source

A Fiber Optic Probe for the Detection of Cataracts [PDF]

, 1993
A compact fiber optic probe developed for on-orbit science experiments was used to detect the onset of cataracts, a capability that could eliminate physicians' guesswork and result in new drugs to 'dissolve' or slow down the cataract formation before ...
Ansari, Rafat R., Dhadwal, Harbans S.
core   +1 more source

Do the fundamental constants change with time ?

, 2008
Comparisons between the redshifts of spectral lines from cosmologically-distant galaxies can be used to probe temporal changes in low-energy fundamental constants like the fine structure constant and the proton-electron mass ratio.
Ivanchik A. V., NISSIM KANEKAR, Thompson R. I., van Langevelde H. J., Varshalovich D. A., Wiklind T., Wiklind T.   +6 more
core   +1 more source

Recent advances in experimental techniques to probe fast excited-state dynamics in biological molecules in the gas phase : dynamics in nucleotides, amino acids and beyond [PDF]

, 2013
In many chemical reactions, an activation barrier must be overcome before a chemical transformation can occur. As such, understanding the behaviour of molecules in energetically excited states is critical to understanding the chemical changes that these ...
Hadden DJ, Lodish H, Rossle S, Satzger H, Scoles G, Vastola FJ, Yang X   +6 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source