Results 81 to 90 of about 279,526 (309)

Force probe molecular dynamics simulations

, 2005
Many proteins are molecular nano-machines, which perform their biological function via well-coordinated structural transitions. Often, these motions occur on much slower time scales than those accessible to conventional molecular dynamics techniques ...
Grubmüller, Helmut, Nienhaus, Ulrich G.
core   +1 more source

Probing chirality with a femtosecond reaction microscope

EPJ Web of Conferences, 2013
Detection of molecular chirality with high sensitivity and selectivity is important for many analytical and practical applications. Photoionization has emerged as a very sensitive probe of chirality in molecules.
Janssen M. H. M., Lehmann C. S., Bhargava Ram N.   +2 more
doaj   +1 more source

Sensitive force technique to probe molecular adhesion and structural linkages at biological interfaces

Biophysical Journal, 1995
Adhesion and cytoskeletal structure are intimately related in biological cell function. Even with the vast amount of biological and biochemical data that exist, little is known at the molecular level about physical mechanisms involved in attachments between cells or about consequences of adhesion on the material structure. To expose physical actions at
Evans, E., Ritchie, K., Merkel, R.
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Solid-state NMR studies of inclusion compounds [PDF]

, 1997
The work contained within this thesis is a study of inclusion compounds using solid-state NMR. Such compounds typically exhibit static and/or dynamic disorder, which precludes the use of diffraction-based techniques to obtain detailed structural ...
Nordon, Alison
core  

Chemoproteomics, A Broad Avenue to Target Deconvolution

Advanced Science
As a vital project of forward chemical genetic research, target deconvolution aims to identify the molecular targets of an active hit compound.
Yihui Gao, Mingzhe Ma, Wenyang Li, Xiaoguang Lei   +3 more
doaj   +1 more source

Ramanomics: New Omics Disciplines Using Micro Raman Spectrometry with Biomolecular Component Analysis for Molecular Profiling of Biological Structures

Biosensors, 2017
Modern instrumentation for Raman microspectroscopy and current techniques in analysis of spectral data provide new opportunities to study molecular interactions and dynamics at subcellular levels in biological systems.
Andrey N. Kuzmin, Artem Pliss, Paras N. Prasad   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Knowledge-based gene expression classification via matrix factorization

, 2008
Motivation: Modern machine learning methods based on matrix decomposition techniques, like independent component analysis (ICA) or non-negative matrix factorization (NMF), provide new and efficient analysis tools which are currently explored to analyze ...
Schachtner, R., Lang, E. W., Tomé, A. M., Gómez Vilda, P., Vilda, P.G., Theis, Fabian J., Theis, F. J., Knollmüller, P., Schmitz, G., Lang, Elmar, Lang, E.W., Lutter, D., Stetter, M., Theis, F.J., Tomé, A.M.   +14 more
core   +1 more source