Results 201 to 210 of about 272,652 (264)

Designing life science assessments in the era of generative artificial intelligence. [PDF]

PLoS One
Kwong AC, Magnano C, DeOliveira C, Goglia C, Loparo JJ, Peters JJ.   +5 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Single-Domain Antibody Probe with Low Renal Uptake for Claudin 18.2-Targeted PET Imaging of Gastric Cancer: Preclinical and Pilot Clinical Evaluations. [PDF]

J Nucl Med
Zheng M, Ma H, Xu T, Mu H, Liu Q, Zhang K, Bian Y, Zhang H, Li W, Zhang B, Shan Y, Peng X, Qin S, Wang Y, Miao L.   +14 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Emerging In Vivo Imaging Modalities for Improved Glioblastoma Surgery and Monitoring. [PDF]

Biomedicines
Dada O, Singh S, Sumadchat F, Lather M, Brooks B, Allgood JE.   +5 more
europepmc   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Integrating simultaneous interfacial shear rheology with neutron reflectometry for structural and dynamic analysis of fluid interfacial systems. [PDF]

J Appl Crystallogr
Sánchez-Puga P, Tajuelo J, Carrascosa-Tejedor J, Rubio MÁ, Gutfreund P, Maestro A.   +5 more
europepmc   +1 more source

Diagnostic yield and safety of needle-based COnfocaL LAser endomicroscopy and ultrasound-guided pleural BiOpsy in diagnosing patients with unknown pleuRAl effusion: a protocol for a mulTIcenter, randomized cONtrolled trial (COLLABORATION-II). [PDF]

Respir Res
Zheng Z, Ye S, Liu X, Xiao K, Deng M, Tong R, Porcel JM, Wang T, Hou G.   +8 more
europepmc   +1 more source

Achieving Single-Cell Resolution via Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI) on Different Platforms. [PDF]

Anal Chem
Colwell N, Chen D, Bhusal D, Peng Z, Yang Z.   +4 more
europepmc   +1 more source