Results 31 to 40 of about 264,869 (298)

In Vivo Tomographic Imaging of Near-Infrared Fluorescent Probes

Molecular Imaging, 2002
Fluorescence imaging is increasingly used to probe protein function and gene expression in live animals. This technology could enhance the study of pathogenesis, drug development, and therapeutic intervention.
Vasilis Ntziachristos, Christoph Bremer, Edward E. Graves, Jorge Ripoll, Ralph Weissleder   +4 more
doaj   +1 more source

Biomembrane force probe (BFP): Design, advancements, and recent applications to live‐cell mechanobiology

Exploration, 2023
Mechanical forces play a vital role in biological processes at molecular and cellular levels, significantly impacting various diseases such as cancer, cardiovascular disease, and COVID‐19.
Laura Moldovan, Caroline Haoran Song, Yiyao Catherine Chen, Haoqing Jerry Wang, Lining Arnold Ju   +4 more
doaj   +1 more source

Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model

EJNMMI Research, 2020
Purpose The reoperation rate for breast-conserving surgery is as high as 15–30% due to residual tumor in the surgical cavity after surgery. In vivo tumor-targeted optical molecular imaging may serve as a red-flag technique to improve intraoperative ...
Frans V. Suurs, Si-Qi Qiu, Joshua J. Yim, Carolien P. Schröder, Hetty Timmer-Bosscha, Eric S. Bensen, John T. Santini, Elisabeth G. E. de Vries, Matthew Bogyo, Gooitzen M. van Dam   +9 more
doaj   +1 more source

Trends in Single-Molecule Total Internal Reflection Fluorescence Imaging and Their Biological Applications with Lab-on-a-Chip Technology

Sensors, 2023
Single-molecule imaging technologies, especially those based on fluorescence, have been developed to probe both the equilibrium and dynamic properties of biomolecules at the single-molecular and quantitative levels. In this review, we provide an overview
Louis Colson, Youngeun Kwon, Soobin Nam, Avinashi Bhandari, Nolberto Martinez Maya, Ying Lu, Yongmin Cho   +6 more
doaj   +1 more source

Quantification and localization of oncogenic receptor tyrosine kinase variant transcripts using molecular inversion probes

Scientific Reports, 2018
Oncogenic membrane receptor tyrosine kinases such as MET and EGFR, or auto-active variants thereof, are important targets for cancer precision therapy.
Corina N. A. M. van den Heuvel, Arvid I. Das, Tessa de Bitter, Femke Simmer, Thomas Wurdinger, Miguel Angel Molina-Vila, William P. J. Leenders   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Probing Ordered Lipid Assemblies with Polarized Third-Harmonic-Generation Microscopy

Physical Review X, 2013
Ordered lipid assemblies are responsible for important physiological functions including skin barrier and axon conductivity. However, techniques commonly used to probe molecular order such as X-ray scattering and nuclear magnetic resonance are not suited
Maxwell Zimmerley, Pierre Mahou, Delphine Débarre, Marie-Claire Schanne-Klein, Emmanuel Beaurepaire   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Sum-Frequency Vibrational Spectroscopy on Chiral Liquids: A Novel Technique to Probe Molecular Chirality [PDF]

Physical Review Letters, 2000
Optical activity in sum-frequency vibrational spectra has been observed for the first time in chiral liquids. The electric-dipole allowed chiral element of the nonlinear susceptibility appears to be 3 orders of magnitude smaller than typical allowed achiral elements.
M A, Belkin, T A, Kulakov, K H, Ernst, L, Yan, Y R, Shen   +4 more
openaire   +2 more sources