Results 41 to 50 of about 654,387 (333)

Clinical application of high throughput molecular screening techniques for pharmacogenomics. [PDF]

, 2011
Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples.
Schrijver, Iris, Wiita, Arun P
core   +1 more source

In Vivo Tomographic Imaging of Near-Infrared Fluorescent Probes

Molecular Imaging, 2002
Fluorescence imaging is increasingly used to probe protein function and gene expression in live animals. This technology could enhance the study of pathogenesis, drug development, and therapeutic intervention.
Vasilis Ntziachristos, Christoph Bremer, Edward E. Graves, Jorge Ripoll, Ralph Weissleder   +4 more
doaj   +1 more source

Novel real-time PCR assays for the specific detection of human infective Cryptosporidium species [PDF]

, 2016
Cryptosporidium is a protozoan parasite causing gastrointestinal illness. Drinking waterborne outbreaks have been caused by C. hominis, C. parvum and C. cuniculus.
Bouzid, Maha, Chalmers, Rachel, Elwin, Kristin, Hunter, Paul, Nader, Johanna, Tyler, Kevin   +5 more
core   +1 more source

The origin of high-resolution IETS-STM images of organic molecules with functionalized tips [PDF]

, 2014
Recently, the family of high-resolution scanning probe imaging techniques using decorated tips has been complimented by a method based on inelastic electron tunneling spectroscopy (IETS).
Hapala, Prokop, Jelínek, Pavel, Tautz, F. Stefan, Temirov, Ruslan   +3 more
core   +2 more sources

Biomembrane force probe (BFP): Design, advancements, and recent applications to live‐cell mechanobiology

Exploration, 2023
Mechanical forces play a vital role in biological processes at molecular and cellular levels, significantly impacting various diseases such as cancer, cardiovascular disease, and COVID‐19.
Laura Moldovan, Caroline Haoran Song, Yiyao Catherine Chen, Haoqing Jerry Wang, Lining Arnold Ju   +4 more
doaj   +1 more source

Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model

EJNMMI Research, 2020
Purpose The reoperation rate for breast-conserving surgery is as high as 15–30% due to residual tumor in the surgical cavity after surgery. In vivo tumor-targeted optical molecular imaging may serve as a red-flag technique to improve intraoperative ...
Frans V. Suurs, Si-Qi Qiu, Joshua J. Yim, Carolien P. Schröder, Hetty Timmer-Bosscha, Eric S. Bensen, John T. Santini, Elisabeth G. E. de Vries, Matthew Bogyo, Gooitzen M. van Dam   +9 more
doaj   +1 more source

Measuring the quantum efficiency of single radiating dipoles using a scanning mirror

, 2005
Using scanning probe techniques, we show the controlled manipulation of the radiation from single dipoles. In one experiment we study the modification of the fluorescence lifetime of a single molecular dipole in front of a movable silver mirror. A second
B. C. Buchler, C. Hettich, H. Benisty, J. Macklin, K. Sundararajan, K. G. Sullivan, K. H. Drexhage, L. Novotny, R. R. Chance, T. Kalkbrenner, U. Kreibig, V. Sandoghdar, W. P. Ambrose   +12 more
core   +1 more source

Trends in Single-Molecule Total Internal Reflection Fluorescence Imaging and Their Biological Applications with Lab-on-a-Chip Technology

Sensors, 2023
Single-molecule imaging technologies, especially those based on fluorescence, have been developed to probe both the equilibrium and dynamic properties of biomolecules at the single-molecular and quantitative levels. In this review, we provide an overview
Louis Colson, Youngeun Kwon, Soobin Nam, Avinashi Bhandari, Nolberto Martinez Maya, Ying Lu, Yongmin Cho   +6 more
doaj   +1 more source

Novel deletions causing pseudoxanthoma elasticum underscore the genomic instability of the ABCC6 region [PDF]

, 2010
Mutations in ABCC6 cause pseudoxanthoma elasticum (PXE), a heritable disease that affects elastic fibers. Thus far, >200 mutations have been characterized by various PCR-based techniques (primarily direct sequencing), identifying up to 90% of PXE-causing
Chassaing, N, Costrop, Laura, Coucke, Paul, De Paepe, Anne, Guerra, D, Le Saux, Olivier, Martin, L, Pasquali-Ronchetti, I, Van Laer, Lut, Vanakker, Olivier   +9 more
core   +2 more sources

Quantification and localization of oncogenic receptor tyrosine kinase variant transcripts using molecular inversion probes

Scientific Reports, 2018
Oncogenic membrane receptor tyrosine kinases such as MET and EGFR, or auto-active variants thereof, are important targets for cancer precision therapy.
Corina N. A. M. van den Heuvel, Arvid I. Das, Tessa de Bitter, Femke Simmer, Thomas Wurdinger, Miguel Angel Molina-Vila, William P. J. Leenders   +6 more
doaj   +1 more source