Results 31 to 40 of about 279,526 (309)

Scanning electrochemical microscopy as a local probe of oxygen permeability in cartilage [PDF]

, 2000
The use of scanning electrochemical microscopy, a high-resolution chemical imaging technique, to probe the distribution and mobility of solutes in articular cartilage is described.
O’Hare, Danny, O'Hare, D. (Danny), Gonsalves, Marylou, Unwin, Patrick R., Macpherson, Julie V., Barker, Anna L., Winlove, C. Peter   +6 more
core   +1 more source

Quantitative assessment of LASSO probe assembly and long-read multiplexed cloning

BMC Biotechnology, 2019
Background Long Adapter Single-Stranded Oligonucleotide (LASSO) probes were developed as a novel tool for massively parallel cloning of kilobase-long genomic DNA sequences. LASSO dramatically improves the capture length limit of current DNA padlock probe
Syukri Shukor, Alfred Tamayo, Lorenzo Tosi, H. Benjamin Larman, Biju Parekkadan   +4 more
doaj   +1 more source

In Vivo Tomographic Imaging of Near-Infrared Fluorescent Probes

Molecular Imaging, 2002
Fluorescence imaging is increasingly used to probe protein function and gene expression in live animals. This technology could enhance the study of pathogenesis, drug development, and therapeutic intervention.
Vasilis Ntziachristos, Christoph Bremer, Edward E. Graves, Jorge Ripoll, Ralph Weissleder   +4 more
doaj   +1 more source

Multicolour interphase cytogenetics: 24 chromosome probes, 6 colours, 4 layers [PDF]

, 2011
From the late 1980s onwards, the use of DNA probes to visualise sequences on individual chromosomes (fluorescent in-situ hybridisation - FISH) revolutionised the study of cytogenetics.
Ellis, Michael, A.R. Thornhill, M. Ellis, D. Ioannou, Meershoek, Eric J., D.K. Griffin, Thornhill, Alan R., E.J. Meershoek, Ioannou, Dimitris, Griffin, Darren K.   +9 more
core   +1 more source

Biomembrane force probe (BFP): Design, advancements, and recent applications to live‐cell mechanobiology

Exploration, 2023
Mechanical forces play a vital role in biological processes at molecular and cellular levels, significantly impacting various diseases such as cancer, cardiovascular disease, and COVID‐19.
Laura Moldovan, Caroline Haoran Song, Yiyao Catherine Chen, Haoqing Jerry Wang, Lining Arnold Ju   +4 more
doaj   +1 more source

Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model

EJNMMI Research, 2020
Purpose The reoperation rate for breast-conserving surgery is as high as 15–30% due to residual tumor in the surgical cavity after surgery. In vivo tumor-targeted optical molecular imaging may serve as a red-flag technique to improve intraoperative ...
Frans V. Suurs, Si-Qi Qiu, Joshua J. Yim, Carolien P. Schröder, Hetty Timmer-Bosscha, Eric S. Bensen, John T. Santini, Elisabeth G. E. de Vries, Matthew Bogyo, Gooitzen M. van Dam   +9 more
doaj   +1 more source

Synthesis and Bioconjugation of Gold Nanoparticles as Potential Molecular Probes for Light‐Based Imaging Techniques [PDF]

International Journal of Biomedical Imaging, 2007
We have synthesized and characterized gold nanoparticles (spheres and rods) with optical extinction bands within the “optical imaging window.” The intense plasmon resonant driven absorption and scattering peaks of these nanoparticles make them suitable as contrast agents for optical imaging techniques.
Raja Gopal Rayavarapu, Wilma Petersen, Constantin Ungureanu, Janine N. Post, Ton G. van Leeuwen, Srirang Manohar   +5 more
openaire   +6 more sources

Time-resolved quantitative assays and imaging of enzymes and enzyme substrates using a new europium fluorescent probe for hydrogen peroxide

, 2005
The thesis describes the development of a novel reversible H2O2 fluorescent probe comprising the ternary complex of europium(III), tetracycline and hydrogen peroxide; and its application in the assays of H2O2, of H2O2 producing oxidases and their ...
Wu, Meng
core   +1 more source

Trends in Single-Molecule Total Internal Reflection Fluorescence Imaging and Their Biological Applications with Lab-on-a-Chip Technology

Sensors, 2023
Single-molecule imaging technologies, especially those based on fluorescence, have been developed to probe both the equilibrium and dynamic properties of biomolecules at the single-molecular and quantitative levels. In this review, we provide an overview
Louis Colson, Youngeun Kwon, Soobin Nam, Avinashi Bhandari, Nolberto Martinez Maya, Ying Lu, Yongmin Cho   +6 more
doaj   +1 more source

Crystal structure of a DNA containing the planar, phenoxazine-derived bi-functional spectroscopic probe Ç

, 2011
Electron Paramagnetic Resonance (EPR) spectroscopy and fluorescence spectroscopy are complementary biophysical techniques used to examine the structure and dynamics of macromolecules.
Reginsson, Gunnar Widtfeldt, Olav Schiemann, Cekan, Pavol, Shelke, Sandip A., Adrian R. Ferré-D’Amaré, Gunnar W. Reginsson, Pavol Cekan, Edwards, Thomas E., Snorri Th. Sigurdsson, Schiemann, Olav, Sigurdsson, Snorri, Thomas E. Edwards, Ferre D'Amare, Adrian R., Sandip A. Shelke   +13 more
core   +1 more source