Results 181 to 190 of about 596,923 (316)

Molecular probes for tracking lipid droplet membrane dynamics. [PDF]

Nat Commun
Kong L, Bai Q, Li C, Wang Q, Wang Y, Shao X, Wei Y, Sun J, Yu Z, Yin J, Shi B, Fang H, Chen X, Chen Q.   +13 more
europepmc   +1 more source

cCPE Fusion Proteins as Molecular Probes to Detect Claudins and Tight Junction Dysregulation in Gastrointestinal Cell Lines, Tissue Explants and Patient-Derived Organoids. [PDF]

Pharmaceutics, 2023
Waldow A, Beier LS, Arndt J, Schallenberg S, Vollbrecht C, Bischoff P, Farrera-Sal M, Loch FN, Bojarski C, Schumann M, Winkler L, Kamphues C, Ehlen L, Piontek J.   +13 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Protocol for detecting substrates in living cells by targeted molecular probes through hyperpolarized ¹²⁹Xe MRI. [PDF]

STAR Protoc, 2022
Zeng Q, Guo Q, Yuan Y, Zhang L, Jiang W, Yang Y, Zhou X.   +6 more
europepmc   +1 more source

Femtosecond Filament Interaction As A Probe For Molecular Alignment

, 2013
Erik McKee
openalex   +1 more source

Use of hemopexin domains and monoclonal antibodies to hemopexin to probe the molecular determinants of hemopexin-mediated heme transport.

, 1988
William T. Morgan, P. Muster, Fred M. Tatum, Josie McConnell, Thomas P. Conway, Preston Hensley, Ann Smith   +6 more
openalex   +1 more source

Probing Molecular Dynamics by Laser-Induced Backscattering Holography [PDF]

, 2016
Marko Haertelt, Xue-Bin Bian, Michael Spanner, A. Staudte, P. B. Corkum   +4 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Smart molecular probes with controllable photophysical property for smart medicine. [PDF]

Smart Mol
Kang X, Du Z, Yang S, Liang M, Liu Q, Qi J.   +5 more
europepmc   +1 more source

Affimers and nanobodies as molecular probes and their applications in imaging.

J Cell Sci, 2022
Cordell P, Carrington G, Curd A, Parker F, Tomlinson D, Peckham M.   +5 more
europepmc   +1 more source