Results 201 to 210 of about 631,116 (314)

Redefining Molecular Probes for Monitoring Subcellular Environment: A Perspective. [PDF]

Anal Chem
García S, Carmona-Santiago G, Jiménez-Sánchez A.   +2 more
europepmc   +1 more source

De Novo Development of Mitochondria-Targeted Molecular Probes Targeting Pink1. [PDF]

Int J Mol Sci, 2022
Ben-Uliel SF, Zoabi FH, Slavin M, Sibony-Benyamini H, Kalisman N, Qvit N.   +5 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Covalent functionalization of G protein-coupled receptors by small molecular probes. [PDF]

RSC Chem Biol
Beerkens BLH, IJzerman AP, Heitman LH, van der Es D.   +3 more
europepmc   +1 more source

Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design. [PDF]

Front Chem, 2022
Wang Y, Lin Q, Shi H, Cheng D.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Application of rare earth elements in dual-modality molecular probes. [PDF]

RSC Adv
He JF, Yang WW, Quan WX, Yang YC, Zhang Z, Luo QY.   +5 more
europepmc   +1 more source

Identification and characterization of alternative sites and molecular probes for SARS-CoV-2 target proteins. [PDF]

Front Chem, 2022
Iyengar SM, Barnsley KK, Vu HY, Bongalonta IJA, Herrod AS, Scott JA, Ondrechen MJ.   +6 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Exploring the Application Potential of α-Synuclein Molecular Probes in Early Diagnosis of Parkinson's Disease: Focus on Imaging Methods. [PDF]

ACS Chem Neurosci
Sun Q, Wu M, Xie R, Lai L, Chen Q, Guan J.   +5 more
europepmc   +1 more source