Results 181 to 190 of about 631,116 (314)

MC1R and melanin-based molecular probes for theranostic of melanoma and beyond. [PDF]

Acta Pharmacol Sin, 2022
Shi H, Cheng Z.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Tuning the efficiency of molecular probes <i>via</i> quinone methide-based <i>in situ</i> labeling. [PDF]

RSC Chem Biol
Rabinowitz Z, Anvar S, Liu J, Chen Z, Zhang Y, Cui C, Sigler A, Cui L.   +7 more
europepmc   +1 more source

Looking deep inside tissue with photoacoustic molecular probes: a review. [PDF]

J Biomed Opt, 2022
Hui X, Malik MOA, Pramanik M.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Sensitive Detection of Intercellular Tensile Forces via Cas12a-Assisted Membrane Molecular Probes. [PDF]

Nano Lett
Singuru MMR, Bhattacharyya P, Sriramakrishnan HP, You M.   +3 more
europepmc   +1 more source

Activated molecular probes for enzyme recognition and detection. [PDF]

Theranostics, 2022
Yuan M, Wu Y, Zhao C, Chen Z, Su L, Yang H, Song J.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Bitopic A₃ Adenosine Receptor Molecular Probes: Positive Allosteric Modulation and Noncanonical Activation. [PDF]

J Med Chem
Kurma SH, Pavan M, Wan TC, Pradhan B, López-Cano M, Ciruela F, Gao ZG, Auchampach JA, Jacobson KA.   +8 more
europepmc   +1 more source

Polymeric Nanoparticles with Embedded Eu(III) Complexes as Molecular Probes for Temperature Sensing. [PDF]

Molecules, 2022
Kuznetsov KM, Baigildin VA, Solomatina AI, Galenko EE, Khlebnikov AF, Sokolov VV, Tunik SP, Shakirova JR.   +7 more
europepmc   +1 more source