Results 51 to 60 of about 1,920,958 (265)

Photolysis of interstellar ice analogs containing ethanol: A new approach to forming C2H4O2 isomers

Astronomy & Astrophysics
Context. The three most common of the eight isomers of C2H4O2 - methyl formate (CH3OCHO, MF), glycolaldehyde (CH2OHCHO, GA), and acetic acid (CH3COOH, AA) - are detected in various interstellar clouds, often with differing abundance ratios.
Lemaitre Maya, Krim Lahouari, Pagani Laurent   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Fine and hyperfine (de-)excitation of C4H (X2Σ+) by collisions with He at low temperatures

Astronomy & Astrophysics
We present a quantum scattering study of the fine and hyperfine rotational (de-)excitation of the linear carbon-chain radical C4H (X2Σ+) in collisions with helium atoms at low temperatures relevant to the interstellar medium (ISM).
Mehnen Bilel, Hendaoui Hamza, Ben Abdallah Driss, Hochlaf Majdi   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

In situ characterization of volatile and refractory hydrocarbons produced by UV photolysis of interstellar C2H2 ice

Astronomy & Astrophysics
Context. Acetylene (C2H2) has been commonly observed in various astronomical objects, including star-forming regions, young stellar objects, and our Solar System.
Samarth P., Fedoseev G., Bulak M., Ioppolo S., Hornekær L., van Dishoeck E. F., Linnartz H., Chuang K.-J.   +7 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The Nucleated Atomistic Grain Growth Simulator (NAGGS): application to the size-dependent structural and physical properties of nanosilicate dust

Astronomy & Astrophysics
Context. The essential physics of dust grains are typically rationalised using phenomenological approaches, often assuming highly simplified grain morphologies.
Mariñoso Guiu Joan, Maciá Escatllar Antoni, Bromley Stefan T.   +2 more
doaj   +1 more source

Comprehensive Identification of Bridge Genes to Explain the Progression from Chronic Hepatitis B Virus Infection to Hepatocellular Carcinoma

Journal of Inflammation Research, 2021
Wenwei Nong,1,* Liping Ma,2,* Biyang Lan,1 Ning Liu,1 Hongzhi Yang,1 Xiaoxia Lao,2 Qiaomei Deng,2 Zhihu Huang2 1Department of General Surgery, Affiliated Minzu Hospital of Guangxi Medical University, Nanning, People’s Republic of China; 2Department
Nong W, Ma L, Lan B, Liu N, Yang H, Lao X, Deng Q, Huang Z   +7 more
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Methanimine as a sink in the HCN and HNC solid state hydrogenation network

Astronomy & Astrophysics
Aims. We aim to provide a systematic and quantitative description of the hydrogenation network connecting HCN and HNC to methylamine on interstellar water ices, and to identify the dominant reaction pathways and potential bottlenecks. Methods.
Enrique-Romero J., Lamberts T.
doaj   +1 more source