Results 61 to 70 of about 1,920,958 (265)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Isotopic effects in rotational de-excitation of H2CO isotopologues (HDCO and D2CO) by He at low temperatures

Astronomy & Astrophysics
Context. In typical interstellar molecular clouds, densities are low; therefore, the analysis of observed molecular spectra requires using non-LTE models. Critical inputs for these models are collisional rate coefficients of the detected molecule with He
Santelices Rosas Salvador, Cabrera-González Lisan D., Cárdenas Carlos, Denis-Apizar Otoniel   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Revisiting the formation of molecules and dust in core collapse supernovae

Astronomy & Astrophysics
Context. Core-collapse Supernovae (CCSNe) classed as Type II contribute to the chemical enrichment of galaxies through explosion. Their role as dust producers in the high-redshift Universe may be of paramount importance.
Cherchneff I., Talbi D., Cernicharo J.
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Irinotecan's molecular mechanisms against cancer: a primary system biology and chemoinformatics approach for novel formulation development

Current Issues in Pharmacy and Medical Sciences
Cancer is the third most common type of cancer generally. It affects 6.1% of the entire world’s population and kills 9.2% of all people of both sexes. Even though people with colon cancer have a number of chemotherapies and surgeries to choose from, the
Eknath D. Ahire, Sanjay J. Kshirsagar
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Quantifying the temperature-dependent yields of N2 and N2H4 formation in vacuum-ultraviolet-irradiated NH3 ice

Astronomy & Astrophysics
Context. Gas–grain astrochemical models commonly predict that a substantial fraction of elemental nitrogen in dense cores and protoplanetary disks is locked up in molecular nitrogen (N2), either in the gas or ice phase. However, the direct identification
Samarth P., Fedoseev G., Ioppolo S., Hornekær L., van Dishoeck E. F., Chuang K.-J.   +5 more
doaj   +1 more source

Molecular Switches as Platforms for Information Processing

CHIMIA, 2014
This article shows how to teach molecules the basics of logic and how to integrate complicated logic operations with relatively simple molecules. A special focus is put on the realization of multi-level fluorescent switches with chemical inputs as well as on the demonstration of various memory-based operations with all-optical photochromic ...
openaire   +5 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source