Results 121 to 130 of about 1,679,089 (219)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Exploiting the Molecular Properties of Fibrinogen to Control Bleeding Following Vascular Injury. [PDF]

Int J Mol Sci
Singh T, Hasan M, Gaule TG, Ajjan RA.
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

MolFCL: predicting molecular properties through chemistry-guided contrastive and prompt learning. [PDF]

Bioinformatics
Tang X, Zhao Q, Wang J, Duan G.
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Quantum chemical study of molecular properties of small branched-chain amino acids in water. [PDF]

Amino Acids
Boča R, Rádiková Ž, Štofko J, Vranovičová B, Rajnák C.   +4 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Nipocalimab, an immunoselective FcRn blocker that lowers IgG and has unique molecular properties. [PDF]

MAbs
Seth NP, Xu R, DuPrie M, Choudhury A, Sihapong S, Tyler S, Meador J, Avery W, Cochran E, Daly T, Brown J, Rutitzky L, Markowitz L, Kumar S, Beavers T, Bhattacharya S, Chen H, Parge V, Price K, Wang Y, Sukumaran S, Pao Y, Abouzahr K, Elwood F, Duffner J, Roy S, Narayanaswami P, Hubbard JJ, Ling LE.   +28 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Identifying Molecular Properties of Ataxin-2 Inhibitors for Spinocerebellar Ataxia Type 2 Utilizing High-Throughput Screening and Machine Learning. [PDF]

Biology (Basel)
Sahay S, Wen J, Scoles DR, Simeonov A, Dexheimer TS, Jadhav A, Kales SC, Sun H, Pulst SM, Facelli JC, Jones DE.   +10 more
europepmc   +1 more source