Results 91 to 100 of about 6,845,981 (383)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Facile and Controllable Fabrication of Protein-Only Nanoparticles through Photo-Induced Crosslinking of Albumin and Their Application as DOX Carriers

open access: yesNanomaterials, 2019
Protein-based nanoparticles, as an alternative to conventional polymer-based nanoparticles, offer great advantages in biomedical applications owing to their functional and biocompatible characteristics.
Xiangyu Long   +4 more
doaj   +1 more source

Decoding Pure Rotational Molecular Spectra for Asymmetric Molecules [PDF]

open access: yes, 2012
In this paper we demonstrate how asymmetric molecular rotational spectra may be introduced to students both "pictorially" and with simple formulae. It is shown that the interpretation of such spectra relies heavily upon pattern recognition.
Cooke, S. A., Ohring, P.
core   +3 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

MiR‐195 and miR‐497 suppress tumorigenesis in lung cancer by inhibiting SMURF2‐induced TGF‐β receptor I ubiquitination

open access: yesMolecular Oncology, 2019
SMURF2 is a member of the HECT family of E3 ubiquitin ligases that have important roles as a negative regulator of transforming growth factor‐β (TGF‐β) signaling through ubiquitin‐mediated degradation of TGF‐β receptor I.
Dong‐Kyu Chae   +8 more
doaj   +1 more source

Dry and wet interfaces: Influence of solvent particles on molecular recognition

open access: yes, 2009
We present a coarse-grained lattice model to study the influence of water on the recognition process of two rigid proteins. The basic model is formulated in terms of the hydrophobic effect.
B. Alberts   +7 more
core   +1 more source

Dreaming of atmospheres [PDF]

open access: yes, 2016
Here we introduce the RobERt (Robotic Exoplanet Recognition) algorithm for the classification of exoplanetary emission spectra. Spectral retrievals of exoplanetary atmospheres frequently requires the preselection of molecular/atomic opacities to be ...
Waldmann, I. P.
core   +2 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

Dual transition metal electrocatalysis for difluoromethylation of Aryl halides using potassium difluoroacetate

open access: yesNature Communications
The development of robust, practical, and chemoselective methods for introducing the difluoromethyl (CF₂H) group into organic molecules is highly sought after in the fields of pharmaceutical and agrochemical design.
Naifu Zhou, Mingding Chai, Niankai Fu
doaj   +1 more source

Vicia incisa (Fabaceae). Taxonomical and chorological notes [PDF]

open access: yes, 2017
The classification of the Vicia sativa aggregate is unsatisfactory. Concerning the taxonomic value and choice of rank of some of these taxa, there are disagreements among botanists.
Abbate, G., Iamonico, D., Iberite, M.
core   +1 more source

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