Results 91 to 100 of about 7,543,664 (335)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Facile and Controllable Fabrication of Protein-Only Nanoparticles through Photo-Induced Crosslinking of Albumin and Their Application as DOX Carriers

Nanomaterials, 2019
Protein-based nanoparticles, as an alternative to conventional polymer-based nanoparticles, offer great advantages in biomedical applications owing to their functional and biocompatible characteristics.
Xiangyu Long, Jun Ren, Chao Zhang, Fangling Ji, Lingyun Jia   +4 more
doaj   +1 more source

Dry and wet interfaces: Influence of solvent particles on molecular recognition

, 2009
We present a coarse-grained lattice model to study the influence of water on the recognition process of two rigid proteins. The basic model is formulated in terms of the hydrophobic effect.
B. Alberts, C. Kleanthous, E. Fischer, H. Flyvbjerg, Hans Behringer, Johannes Taktikos, K. A. Dill, M. B. Jackson   +7 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

MiR‐195 and miR‐497 suppress tumorigenesis in lung cancer by inhibiting SMURF2‐induced TGF‐β receptor I ubiquitination

Molecular Oncology, 2019
SMURF2 is a member of the HECT family of E3 ubiquitin ligases that have important roles as a negative regulator of transforming growth factor‐β (TGF‐β) signaling through ubiquitin‐mediated degradation of TGF‐β receptor I.
Dong‐Kyu Chae, Jinyoung Park, Moonsoo Cho, Eunmi Ban, Mihue Jang, Young Sook Yoo, Eunice EunKyeong Kim, Ja‐Hyun Baik, Eun Joo Song   +8 more
doaj   +1 more source

Expanding the Repertoire of Natural Product-Inspired Ring Pairs for Molecular Recognition of DNA [PDF]

, 2011
A furan amino acid, inspired by the recently discovered proximicin natural products, was incorporated into the scaffold of a DNA-binding hairpin polyamide.
Arcamone F., Belitsky J. M., Best T. P., Boger D. L., Bremer R. E., Chenoweth D. M., Daniel A. Gubler, Dervan P. B., Dervan P. B., Doss R. M., Edelson B. S., Fiedler H. P., Jevgenij A. Raskatov, Jordan L. Meier, Katy A. Muzikar, Kopka M. L., Marques M. A., Matsuda H., Mrksich M., Muzikar K. A., Nickols N. G., Nickols N. G., Olenyuk B. Z., Pelton J. G., Peter B. Dervan, Pilch D. S., Renneberg D., Schneider K., Stover J. S., Wade W. S., White S., Wolter F. E., Woods C. R.   +32 more
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Radically enhanced molecular recognition [PDF]

, 2010
The tendency for viologen radical cations to dimerize has been harnessed to establish a recognition motif based on their ability to form extremely strong inclusion complexes with cyclobis(paraquat-p-phenylene) in its diradical dicationic redox state ...
Belowich, Matthew E., Benítez, Diego, Carmielli, Raanan, Colvin, Michael T., Cotí, Karla K., Fahrenbach, Albert C., Friedman, Douglas C., Goddard, William A., III, Khashab, Niveen, Khatib, Hussam A., Olsen, John-Carl, Stoddart, J. Fraser, Tkatchouk, Ekaterina, Trabolsi, Ali, Wasielewski, Michael R.   +14 more
core  

Molecular recognition by van der Waals interaction between polymers with sequence-specific polarizabilities

, 2015
We analyze van der Waals interactions between two rigid polymers with sequence-specific, anisotropic polarizabilities along the polymer backbones, so that the dipole moments fluctuate parallel to the polymer backbones.
Lu, Bing-Sui, Naji, Ali, Podgornik, Rudolf   +2 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source