Results 81 to 90 of about 813,980 (316)

Facile and Controllable Fabrication of Protein-Only Nanoparticles through Photo-Induced Crosslinking of Albumin and Their Application as DOX Carriers

Nanomaterials, 2019
Protein-based nanoparticles, as an alternative to conventional polymer-based nanoparticles, offer great advantages in biomedical applications owing to their functional and biocompatible characteristics.
Xiangyu Long, Jun Ren, Chao Zhang, Fangling Ji, Lingyun Jia   +4 more
doaj   +1 more source

Solvent Effects in Molecular Recognition. [PDF]

Acta Chemica Scandinavica, 1990
Abstract
D. B. Smithrud, E. M. Sanford, I. Chao, S. B. Ferguson, D. R. Carcanague, J. D. Evanseck, K. N. Houk, F. Diederich   +7 more
openaire   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89 [PDF]

, 1988
The murine cytomegalovirus protein pp89, which is encoded by gene ieI, is a nonstructural regulatory protein expressed in the immediate-early phase of the viral replication cycle and located mainly in the nucleus of infected cells.
Reddehase, Matthias J., Del Val, Margarita, Koszinowski, Ulrich H., Schickedanz, Jörg, Volkmer, Hansjürgen, Messerle, Martin, Jonjic, Stipan, Rothbard, Jonathan B.   +7 more
core  

Exploiting β-Cyclodextrin in Molecular Imprinting for Achieving Recognition of Benzylparaben in Aqueous Media

, 2015
The molecularly imprinted polymer (MIP) based on methacrylic acid functionalized β-cyclodextrin (MAA-β-CD) monomer was synthesized for the purpose of selective recognition of benzylparaben (BzP).
Saliza Asman, Norazilawati Sarih, Sharifah Mohamad   +2 more
core   +1 more source

MiR‐195 and miR‐497 suppress tumorigenesis in lung cancer by inhibiting SMURF2‐induced TGF‐β receptor I ubiquitination

Molecular Oncology, 2019
SMURF2 is a member of the HECT family of E3 ubiquitin ligases that have important roles as a negative regulator of transforming growth factor‐β (TGF‐β) signaling through ubiquitin‐mediated degradation of TGF‐β receptor I.
Dong‐Kyu Chae, Jinyoung Park, Moonsoo Cho, Eunmi Ban, Mihue Jang, Young Sook Yoo, Eunice EunKyeong Kim, Ja‐Hyun Baik, Eun Joo Song   +8 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Warfarin: an environment-dependent switchable molecular probe

, 2010
The complex nature of the structure of the anticoagulant warfarin is reflected in the diversity of binding modes observed in warfarin–protein recognition systems.
Rosengren, Annika M., Karlsson, Björn C. G., Henning Henschel, Ian A. Nicholls, Nicholls, Ian A.,, Karlsson, Björn C. G.,, Björn C. G. Karlsson, Rosengren, Annika M.,, Annika M. Rosengren, Henschel, Henning,, Henschel, Henning   +10 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Dual transition metal electrocatalysis for difluoromethylation of Aryl halides using potassium difluoroacetate

Nature Communications
The development of robust, practical, and chemoselective methods for introducing the difluoromethyl (CF₂H) group into organic molecules is highly sought after in the fields of pharmaceutical and agrochemical design.
Naifu Zhou, Mingding Chai, Niankai Fu
doaj   +1 more source