Results 81 to 90 of about 1,377,862 (341)

Stereoselective rhodium-catalyzed reaction of allenes with organoboronic reagents for diversified branched 1,3-alkadienes

Nature Communications
The terminal isoprene unit, as the simplest branched 1,3-diene unit, exists in a wide range of natural products and bioactive molecules. Herein, we report a stereoselective rhodium-catalyzed reaction of allenes with readily available methyl pinacol ...
Weiyi Wang, Shichao Hong, Wenxiang He, Xue Zhang, Hui Qian, Shengming Ma   +5 more
doaj   +1 more source

MiR‐195 and miR‐497 suppress tumorigenesis in lung cancer by inhibiting SMURF2‐induced TGF‐β receptor I ubiquitination

Molecular Oncology, 2019
SMURF2 is a member of the HECT family of E3 ubiquitin ligases that have important roles as a negative regulator of transforming growth factor‐β (TGF‐β) signaling through ubiquitin‐mediated degradation of TGF‐β receptor I.
Dong‐Kyu Chae, Jinyoung Park, Moonsoo Cho, Eunmi Ban, Mihue Jang, Young Sook Yoo, Eunice EunKyeong Kim, Ja‐Hyun Baik, Eun Joo Song   +8 more
doaj   +1 more source

Mesoporous Silica Materials as an Emerging Tool for Cancer Immunotherapy

Advanced Science, 2022
Cancer immunotherapy has emerged in the past decade as a promising strategy for treating many forms of cancer by stimulating the patient's immune system.
Blanca Escriche‐Navarro, Andrea Escudero, Elena Lucena‐Sánchez, Félix Sancenón, Alba García‐Fernández, Ramón Martínez‐Máñez   +5 more
doaj   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Circularly polarized luminescence with high dissymmetry factors for achiral organic molecules in solutions

Nature Communications
Circularly polarized luminescence (CPL) in solution offers several advantages. However, it remains challenging for organic molecules to achieve circularly polarized luminescence with high dissymmetry factor (g lum) in solution. Herein, a general strategy
Ming-Jun Ji, Wen-Long Zhao, Meng Li, Chuan-Feng Chen   +3 more
doaj   +1 more source

Complexation of 2,6-helic[6]arene and its derivatives with 1,1′-dimethyl-4,4′-bipyridinium salts and protonated 4,4'-bipyridinium salts: an acid–base controllable complexation

Beilstein Journal of Organic Chemistry, 2019
2,6-Helic[6]arene and its derivatives were synthesized, and their complexation with 1,1′-dimethyl-4,4′-bipyridinium and protonated 4,4'-bipyridinium salts were investigated in detail. It was found that the helic[6]arene and its derivatives could all form
Jing Li, Qiang Shi, Ying Han, Chuan-Feng Chen   +3 more
doaj   +1 more source

Facile and Controllable Fabrication of Protein-Only Nanoparticles through Photo-Induced Crosslinking of Albumin and Their Application as DOX Carriers

Nanomaterials, 2019
Protein-based nanoparticles, as an alternative to conventional polymer-based nanoparticles, offer great advantages in biomedical applications owing to their functional and biocompatible characteristics.
Xiangyu Long, Jun Ren, Chao Zhang, Fangling Ji, Lingyun Jia   +4 more
doaj   +1 more source

OLIGOSACCHARIDES AND MOLECULAR RECOGNITION [PDF]

, 2014
Carbohydrates have been established as the most abundant ? and arguably the most structural diverse ? organic molecules found in nature. They are chiral molecules readily available in nature in a variety of diastereomeric forms. Their conformational rigidity provides a well defined three-dimensional spatial arrangement of substituents with various ...
openaire   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Polymer adsorption onto random planar surfaces: Interplay of polymer and surface correlation

, 2005
We study the adsorption of homogeneous or heterogeneous polymers onto heterogeneous planar surfaces with exponentially decaying site-site correlations, using a variational reference system approach.
Alexey Polotsky, Andreas Degenhard, Friederike Schmid, Joanny J.-F.   +3 more
core   +1 more source