Results 161 to 170 of about 393,868 (257)

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Chromosome-level genome assembly and annotation of the kuruma shrimp Marsupenaeus japonicus. [PDF]

Sci Data
Wei Y, Xu H, Zhou Z, Wang P, Cheng W, Huang H, Ding S, Mao Y.   +7 more
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Integrative Genomic and Transcriptomic Analysis of White-Rot Fungi <i>Ganoderma tsugae</i> Growing on Both Coniferous and Broad-Leaved Trees. [PDF]

J Fungi (Basel)
Sun Y, Lv M, Luo M, Yao Z, Zhou M, Fang Y, Wu D, Gao N, Cui B.   +8 more
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Chromosome-Level Genome Assembly of <i>Ormosia henryi</i> Provides Insights into Evolutionary Resilience and Precision Conservation. [PDF]

Plants (Basel)
Tian X, Yuan B, Mou C, Xiang G, Zhu L, Li G, Liu C, Li X, Hu F, Lv H.   +9 more
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

DisProt in 2026: enhancing intrinsically disordered proteins accessibility, deposition, and annotation. [PDF]

Nucleic Acids Res
Nugnes MV, Bouhraoua KEA, Zoubiri M, Pancsa R, Fichó E, DisProt Consortium , Tompa P, Piovesan D, Tosatto SCE, Aspromonte MC.   +9 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

CircleBase V2: an eccDNA annotation platform across cancers and species. [PDF]

Nucleic Acids Res
Wei L, Shi L, Wu N, Zhao H, Wubulikasimu Z, Liu K, Deng M, Mao F, Xiang X, Bi H, Zhao X.   +10 more
europepmc   +1 more source