Results 61 to 70 of about 4,628,843 (306)

The effect of hydrothermal temperature on the properties of SBA-15 materials

Heliyon, 2020
In present work, ordered mesoporous material SBA-15 was synthesized by using poly (alkylene oxide) block copolymer (Pluronic P123) as template and ethylsilicate as silica source in weak acid environment in a wide range of temperature.
Kaiyu Bai, Junsheng Hao, Yongxing Yang, Aniu Qian   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Synthesis of zeolite molecular sieve from coal gangue and its performance on CO2 capture

Meitan xuebao
Coal gangue, a by-product of coal mining, is accumulating rapidly and As a by-product of coal mining, the amount of coal gangue is increasing in stock, which poses a serious threat to the environment.
Cui QUAN, Fudong WANG, Aijun GUO, Tianhua YANG, Rundong LI, Zimou TANG, Ningbo GAO   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A mesoporous molecular sieve-based oral taste-masking agent with efficient shielding effect for oral administration of cetirizine

Nano Research
The bad taste of the drug will seriously affect the patients' medication compliance, after the mesoporous molecular sieve is loaded with the drug, it enters the channel, the amount of drug in contact with the taste buds was significantly reduced, as well
Jiayi Yin, Siyu Jiang, Yingying Li, Shengying Zhu, Yanjing Feng, Yulong Guan, Sun Xiaoya, Gang Wang, Bo Gao   +8 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Patterns of granular convection and separation in narrow vibration bed

EPJ Web of Conferences, 2017
Granular convection/separation of single and binary component particles are studied in a narrow vibration bed, respectively. With filling the single light particles (molecular sieve beads), the bed exhibits five different states successively by ...
Liu Chuanping, Wu Ping, Wang Li, Tong Lige, Yin Shaowu   +4 more
doaj   +1 more source

EQUILIBRIUM ADSORPTION OF METHANE ANDCARBON DIOXIDE ON 5A MOLECULAR SIEVE

Journal of Engineering, 2007
Experimental and theoretical studies have been carried out to study the adsorption of methane and carbon dioxide on 5A molecular sieve. Adsorption equilibrium isotherms of methane and carbon dioxide are reported for the temperature range 303– 333 K and ...
Abbas Khalaf Mohammed Shua'ab
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source