Results 91 to 100 of about 19,554,258 (410)

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

open access: yesFEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet   +4 more
wiley   +1 more source

Probabilistic Generative Deep Learning for Molecular Design [PDF]

open access: yesarXiv, 2019
Probabilistic generative deep learning for molecular design involves the discovery and design of new molecules and analysis of their structure, properties and activities by probabilistic generative models using the deep learning approach. It leverages the existing huge databases and publications of experimental results, and quantum-mechanical ...
arxiv  

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Potassium trihydrogen dioxalate dihydrate (KTO) nonlinear optical (NLO) single crystal for optical limiting application

open access: yesResults in Physics, 2023
In nonlinear optics, optical power limiting (OPL) compounds are known to be an important class of materials because it has the ability to protect the optical sensor components as well as human eyes from the abrupt intense laser power. Here, we have grown
Ramki Chakaravarthy   +5 more
doaj  

Molecular CT: Unifying Geometry and Representation Learning for Molecules at Different Scales [PDF]

open access: yesarXiv, 2020
Deep learning is changing many areas in molecular physics, and it has shown great potential to deliver new solutions to challenging molecular modeling problems. Along with this trend arises the increasing demand of expressive and versatile neural network architectures which are compatible with molecular systems.
arxiv  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

A Cationic Compound of Ru25⊕ Containing a Coordinated PF4O⊖ Ion

open access: yesCHIMIA, 1989
The compound Ru2(PhNNNPh)4 was oxidized in CH2Cl2 with AgPF6. From a CH2Cl2/(C2H5)2O solution left to evaporate in air for one month blue-green crystals of Ru2(PhNNNPh)4OPF4, in which the PF4O⊖ ion is coordinated to one Ru atom (Ru–O: 220(1) pm), were ...
F. Albert Cotton, Marek Matusz
doaj   +1 more source

Discovery of a Molecular Collision Front in Interacting Galaxies NGC 4567/4568 with ALMA [PDF]

open access: yes, 2018
We present results of $^{12}$CO(J = 1-0) imaging observations of NGC 4567/4568, a galaxy pair in a close encounter, with Atacama Large Millimetre/submillimetre Array. For the first time, we find clear evidence of a molecular collision front whose velocity dispersion is 16.8$\pm$1.4 km s$^{-1}$ at the overlapping region owing to high spatial and ...
arxiv   +1 more source

The Equilibrium Structure of Prolate Magnetized Molecular Cores

open access: yes, 2009
The structure of molecular cloud cores supported by thermal pressure and a poloidal magnetic field is reinvestigated in the magnetohydrostatic and axisymmetric approximation.
Basu   +18 more
core   +1 more source

Electrotunable Friction with Ionic Liquid Lubricants: How Important Is the Molecular Structure of the Ions? [PDF]

open access: yesJournal of Physical Chemistry Letters, 2015
Using nonequilibrium molecular dynamics simulations and a coarse-grained model of ionic liquids, we have investigated the impact that the shape and the intramolecular charge distribution of the ions have on the electrotunable friction with ionic liquid ...
O. Y. Fajardo   +3 more
semanticscholar   +1 more source

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