Results 101 to 110 of about 19,554,258 (410)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions

Scientific Reports
Phosphorylation plays a crucial role in the regulation of many fundamental cellular processes. Phosphorylation levels are increased in many cancer cells where they may promote changes in mitochondrial homeostasis.
Nina Kunová, Gabriela Ondrovičová, Jacob A. Bauer, Veronika Krajčovičová, Matyáš Pinkas, Barbora Stojkovičová, Henrieta Havalová, Veronika Lukáčová, Lenka Kohútová, Július Košťan, Lucia Martináková, Peter Baráth, Jiří Nováček, Sebastian Zoll, Sami Kereϊche, Eva Kutejová, Vladimír Pevala   +16 more
doaj   +1 more source

Sparse Representation of Gaussian Molecular Surface [PDF]

arXiv, 2019
In this paper, we propose a model and algorithm for sparse representing Gaussian molecular surface. The original Gaussian molecular surface is approximated by a relatively small number of radial basis functions (RBFs) with rotational ellipsoid feature. The sparsity of the RBF representation is achieved by solving a nonlinear $L_1$ optimization problem.
arxiv  

Markov Field Models: scaling molecular kinetics approaches to large molecular machines [PDF]

arXiv, 2022
With recent advances in structural biology, including experimental techniques and deep learning-enabled high-precision structure predictions, molecular dynamics methods that scale up to large biomolecular systems are required. Current state-of-the-art approaches in molecular dynamics modeling focus on encoding global configurations of molecular systems
arxiv  

Recent developments in the general atomic and molecular electronic structure system.

Journal of Chemical Physics, 2020
A discussion of many of the recently implemented features of GAMESS (General Atomic and Molecular Electronic Structure System) and LibCChem (the C++ CPU/GPU library associated with GAMESS) is presented.
G. Barca, C. Bertoni, L. Carrington, D. Datta, N. D. De Silva, J. E. Deustua, D. Fedorov, J. R. Gour, A. Gunina, Emilie B. Guidez, Taylor Harville, S. Irle, J. Ivanic, K. Kowalski, Sarom S. Leang, Hui Li, Wei Li, J. Lutz, I. Magoulas, J. Mato, V. Mironov, H. Nakata, Buu Q. Pham, P. Piecuch, David L. Poole, Spencer R Pruitt, Alistair P. Rendell, Luke B Roskop, K. Ruedenberg, Tosaporn Sattasathuchana, Michael W. Schmidt, Jun Shen, L. Slipchenko, M. Sosonkina, Vaibhav Sundriyal, Ananta Tiwari, Jorge L. Galvez Vallejo, Bryce M. Westheimer, M. Włoch, Peng Xu, F. Zahariev, Mark S. Gordon   +41 more
semanticscholar   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation

Communications Chemistry
Deubiquitinating enzymes (DUBs) are key regulators of cellular homoeostasis, and their dysregulation is associated with several human diseases. The ovarian tumour protease (OTU) family of DUBs are biochemically well-characterised and of therapeutic ...
Aini Vuorinen, Cassandra R. Kennedy, Katherine A. McPhie, William McCarthy, Jonathan Pettinger, J. Mark Skehel, David House, Jacob T. Bush, Katrin Rittinger   +8 more
doaj   +1 more source

Molecular Fine Structure from Water Window X-rays [PDF]

, 2014
Postprint (published ...
Biegert, Jens, Cousin, Seth L., Hemmer, M., Silva, Francisco, Teichmann, Stephan   +4 more
core   +1 more source

Competitive Solvation of the Imidazolium Cation by Water and Methanol

, 2014
Imidazolium-based ionic liquids are widely used in conjunction with molecular liquids for various applications. Solvation, miscibility and similar properties are of fundamental importance for successful implementation of theoretical schemes.
Chaban, Vitaly
core   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source