Results 151 to 160 of about 19,554,258 (410)
Nature CommunicationsIn mammals, brown adipose tissue (BAT) and inguinal white adipose tissue (iWAT) execute sequential thermogenesis to maintain body temperature during cold stimuli.
Yong Geun Jeon +18 more
doaj +1 more source
Impaired Resolution of Inflammation in the Endoglin Heterozygous Mouse Model of Chronic Colitis
Mediators of Inflammation, 2014 Endoglin is a coreceptor of the TGF-β superfamily predominantly expressed on the vascular endothelium and selective subsets of immune cells. We previously demonstrated that Endoglin heterozygous (Eng+/−) mice subjected to dextran sulfate sodium (DSS ...
Madonna R. Peter +12 more
doaj +1 more source
The crystal and molecular structure of 3:4:5:6:9:10:11:12-octahydrochrysene [PDF]
, 1958 W. G. Ferrier, J. Iball
openalex +1 more source
Molecular Oncology, EarlyView.Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran +16 more
wiley +1 more source
MOL-Mamba: Enhancing Molecular Representation with Structural & Electronic Insights [PDF]
arXivMolecular representation learning plays a crucial role in various downstream tasks, such as molecular property prediction and drug design. To accurately represent molecules, Graph Neural Networks (GNNs) and Graph Transformers (GTs) have shown potential in the realm of self-supervised pretraining.
arxiv
Understanding the Results of Electrostatics Calculations: Visualizing Molecular 'Isopotential' Surfaces [PDF]
arXiv, 2016 This document attempts to clarify potential confusion regarding electrostatics calculations, specifically in the context of biomolecular structure and specifically as regards the units typically used to contour/visualize isopotential surfaces, potentials mapped onto molecular solvent-accessible surfaces, etc.
arxiv
Structures of molecular addition compounds. II. Methyl cyanide–boron trifluoride, H3CCN–BF3 [PDF]
, 1950 J. L. Hoard +3 more
openalex +1 more source
The molecular structure of mammalian primary cilia revealed by cryo-electron tomography
Nature Structural & Molecular Biology, 2020 P. Kiesel +7 more
semanticscholar +1 more source
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source