Results 61 to 70 of about 5,797,712 (321)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Diazocine-functionalized TATA platforms
Beilstein Journal of Organic Chemistry, 2019 Recently, it has been shown that the thermochemical cis→trans isomerization of azobenzenes is accelerated by a factor of more than 1000 by electronic coupling to a gold surface via a conjugated system with 11 bonds and a distance of 14 Å.
Roland Löw +4 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Local structural preferences in shaping tau amyloid polymorphism
Nature CommunicationsTauopathies encompass a group of neurodegenerative disorders characterised by diverse tau amyloid fibril structures. The persistence of polymorphism across tauopathies suggests that distinct pathological conditions dictate the adopted polymorph for each ...
Nikolaos Louros +16 more
doaj +1 more source
An azobenzene container showing a definite folding – synthesis and structural investigation
Beilstein Journal of Organic Chemistry, 2019 The combination of photo-switchable units with macrocycles is a very interesting field in supramolecular chemistry. Here, we present the synthesis of a foldable container consisting of two different types of Lissoclinum macrocyclic peptides which are ...
Abdulselam Adam +2 more
doaj +1 more source
Molecules, 2020 We report data on the structural dynamics of the neuropeptide Y (NPY) G-protein-coupled receptor (GPCR) type 1 (Y1R), a typical representative of class A peptide ligand GPCRs, using a combination of solid-state NMR and molecular dynamics (MD) simulation.
Alexander Vogel +9 more
doaj +1 more source
Light‐Fueled Climbing of Monolithic Torsional Soft Robots via Molecular Engineering
Advanced Intelligent Systems, 2022 Azobenzene‐functionalized liquid crystalline polymer networks (azo‐LCNs) are promising candidates for light‐fueled contactless manipulation of miniaturized soft robots through embedding photoactive molecular switches into alignment‐programmable LCNs.
Jae Gwang Kim +7 more
doaj +1 more source
Molecules, 2022 This contribution employs quantum chemistry methods to describe the variations of the second nonlinear optical responses of molecular switches based on benzazolo-oxazolidine (BOX) units, connected by π-linkers, along their successive opening/closing ...
Pierre Beaujean +4 more
doaj +1 more source
Signal Recognition Particle (SRP) and SRP Receptor: A New Paradigm for Multistate Regulatory GTPases [PDF]
, 2009 The GTP-binding proteins or GTPases comprise a superfamily of proteins that provide molecular switches in numerous cellular processes. The “GTPase switch” paradigm, in which a GTPase acts as a bimodal switch that is turned “on” and “off” by external ...
Schmid, Sandra L. +2 more
core +2 more sources
Molecular switches and cages [PDF]
Beilstein Journal of Organic Chemistry, 2012 Molecular switches can toggle between two (or more) stable states encoding different physical features. They allow complex systems to respond to changes in their environment defined by light intensity, pH, temperature or voltage. As such, molecular switches play a key role in biology and information technology and have become important components of ...
openaire +3 more sources