Results 91 to 100 of about 2,569,624 (298)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
A 2023–2024 Literature Review of Validation Standards and Diagnostic Accuracy
PhytoFrontiersThis study evaluated the progress in validating plant pathogen diagnostic assays by comparing recent literature (2023 to 2024) with previous assessments, particularly following the recommendations of Sharma and Luster (2023).
Daniele M. Nascimento +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Resonant photon absorption in the low spin molecule V15
, 2004 We report the first study of the micro-SQUID response of a molecular system to electromagnetic radiation. The advantages of our micro-SQUID technique in respect to pulsed electron paramagnetic resonance (EPR) techniques consist in the possibility to ...
Barbara, B. +3 more
core +2 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
The results of a two-year investigation into the possibility of developing continuous wave excimer lasers are reported. The program included the evaluation and selection of candidate molecular systems and discharge pumping techniques. The K Ar/K2 excimer
Hess, L. D. +3 more
core +1 more source
Spectroscopy of Ultracold, Trapped Cesium Feshbach Molecules
, 2007 We explore the rich internal structure of Cs_2 Feshbach molecules. Pure ultracold molecular samples are prepared in a CO_2-laser trap, and a multitude of weakly bound states is populated by elaborate magnetic-field ramping techniques.
C. Chin +11 more
core +1 more source
Al-Kitab Journal for Pure SciencesCandida spp. is a naturally occurring bacteria in the GI tracts of numerous species, including birds. Candidiasis is an opportunistic illness that emerges when the normal microflora is disturbed.
Hawraa F.H. Al-abedi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source