Results 91 to 100 of about 2,997,351 (334)

The Hypoglycemic Activity of Gracilaria lemaneiformis Polysaccharide Gels Based on IR/IRS-2/PI3k/Akt/Glut4 and Glycometabolism Signaling Pathways in HepG2 Cells

Gels
The aim of this study was to investigate the hypoglycemic activity and mechanism of G. lemaneiformis polysaccharide gels (GLP and GLP-HV) based on IR/IRS-2/PI3k/Akt/Glut4 and glycometabolism signaling pathways in HepG2 cells.
Xiaoshan Long, Shucheng Liu, Xianqing Yang, Yongqiang Zhao, Shaoling Yang, Ya Wei, Chuang Pan, Shengjun Chen, Peihong Jiang, Bo Qi, Xiao Hu   +10 more
doaj   +1 more source

Influence of Hyaluronic Acid Transitions in Tumor Microenvironment on Glioblastoma Malignancy and Invasive Behavior

Frontiers in Materials, 2018
The extracellular matrix (ECM) is critical in tumor growth and invasive potential of cancer cells. In glioblastoma tumors, some components of the native brain ECM such as hyaluronic acid (HA) have been suggested as key regulators of processes associated ...
Jee-Wei E. Chen, Sara Pedron, Peter Shyu, Yuhang Hu, Jann N. Sarkaria, Brendan A. C. Harley, Brendan A. C. Harley   +6 more
doaj   +1 more source

Molecular Weights of liquids [PDF]

The Journal of Physical Chemistry, 1898
n ...
openaire   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Screening of Lentinula edodes Strains for High Polysaccharide Production and In Vitro Antioxidant Activities

Journal of Fungi
Lentinan is one of the main metabolites of Lentinula edodes and exhibits numerous biological properties, such as antitumor and antioxidant activity. Despite recent advancements, its commercialization remains constrained by a lengthy cultivation cycle ...
Jie Zhang, Kanwal Rida, Jiahao Wen, Xiumei Yu, Yunfu Gu, Maoqiang He, Qiang Chen, Quanju Xiang   +7 more
doaj   +1 more source

Circadian Timing of Food Intake Contributes to Weight Gain [PDF]

, 2009
Studies of body weight regulation have focused almost entirely on caloric intake and energy expenditure. However, a number of recent studies in animals linking energy regulation and the circadian clock at the molecular, physiological, and behavioral ...
Aaron D. Laposky, Arble, Colles, Damiola, Deanna M. Arble, Elfhag, Fabricatore, Fred W. Turek, Joseph Bass, Kohsaka, Kopelman, Laposky, Ma, Martha H. Vitaterna, O'Reardon, Pasinetti, Scheer, Spiegel, Turek   +18 more
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Molecular Weight Dependence of Spreading Rates of Ultrathin Polymeric Films

, 1998
We study experimentally the molecular weight $M$ dependence of spreading rates of molecularly thin precursor films, growing at the bottom of droplets of polymer liquids.
A. M. Cazabat, B. G. Min, D. Ausserré, D. Ausserré, F. Heslot, F. Heslot, G. Oshanin, H. E. Johnson, H. E. Johnson, J. F. Joanny, J. F. Joanny, L. Leger, M. Moreau, M. P. Valignat, N. Fraysse, P. G. de Gennes, P. G. de Gennes, P. G. de Gennes, P. G. de Gennes, R. Bruinsma, R. M. A. Azzam, S. F. Burlatsky, S. Villette, S. Villette, V. J. Novotny   +24 more
core   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source