Results 81 to 90 of about 6,897,562 (308)
Impact of pharmaceutical care on self-administration of outpatient low-molecular-weight heparin therapy [PDF]
, 2014 Outpatient subcutaneous (s.c.) therapies are becoming more and more common in the treatmentof different diseases. The effectiveness of community-pharmacy-based interventions in preventingproblems that arise during s.c.
Kurt E. Hersberger +13 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2018 The biorecalcitrant dissolved organic matter (DOM) and colorants in biochemically treated effluent, known for their complex and indefinite composition, are drawing increasing environmental concern in the distillery industry.
Li Xie (108913) +4 more
core +1 more source
THE MOLECULAR WEIGHT OF CRYSTALLINE CATALASE
Journal of Biological Chemistry, 1938 Sumner, James B., Gralen, N. The Molecular Weight of Crystalline Catalase, 1938 ; https://digitalcommons.rockefeller.edu/pamphlets-offprints-and-reprints/1046/thumbnail ...
Sumner, James B., Gralen, Nils
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Examination of the Molecular Mass of Polyhydroxypolyamides [PDF]
, 2010 The work described in this thesis investigated the use of size exclusion chromatography (SEC) to fractionate a variety of different polyhydroxypolyamide (PHPA) samples for analysis by matrix assisted laser desorption ionisation-time of flight ...
Faville, Martyn
core
, 2023 We report a method to synthesize ultra-high-molecular-weight poly(1,3-dioxolane) (UHMW pDXL), a chemically recyclable thermoplastic material with excellent physical properties.
Brooks A. Abel (1422769) +2 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source