Results 121 to 130 of about 9,504,025 (387)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes [PDF]

, 1986
Several cDNA clones coding for the high molecular weight (alpha) subunit of the voltage-sensitive Na channel have been selected by immunoscreening a rat brain cDNA library constructed in the expression vector lambda gt11.
Auld, Vanessa, Catterall, William A., Davidson, Norman, Downey, William, Dowsett, Andrew, Dunn, Robert, Fritz, Larry C., Goldin, Alan L., Lester, Henry A., Lübbert, Hermann, Marshall, John, Snutch, Terry P.   +11 more
core  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Funcionalização do Polipropileno com Viniltrietoxisilano em Solução e no Estado Fundido Polypropylene functionalization with vinyltrietho-xysilane in solution and in melt state

Polímeros, 1998
RESUMO: Polipropileno (PP) foi funcionalizado com viniltrietoxisilano (VTES) em solução e no estado fundido, utilizando peróxidos como iniciadores. A influência da concentração de silano e de peróxido sobre o grau de funcionalização foi avaliada por ...
Sônia M. B. Nachtigall, Afonso H. O. Felix, Telmo Ojeda, Raquel S. Mauler   +3 more
doaj   +1 more source

Hydropyrolysis of high molecular weight organic matter in Murchison [PDF]

, 2003
Hydropyrolysis of the Murchison macromolecular material releases polyaromatic compounds including phenanthrene, carbazole, fluoranthene, pyrene, chrysene, perylene, benzoperylene and coronene units with varying degrees of ...
Gilmour, I, Love, G. D., Sephton, M. A., Snape, C. E., Verchovsky, A. B., Watson, J. S., Wright, I. P.   +6 more
core  

Effects of Bulk Composition on The Atmospheric Dynamics on Close-in Exoplanets

, 2017
Super Earths and mini Neptunes likely have a wide range of atmospheric compositions, ranging from low-molecular mass atmospheres of H2 to higher molecular atmospheres of water, CO2, N2, or other species. Here, we systematically investigate the effects of
Showman, Adam P., Zhang, Xi
core   +2 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

AN UNUSUAL PROTEIN COMPONENT OF HIGH MOLECULAR WEIGHT IN THE SERUM OF CERTAIN PATIENTS WITH RHEUMATOID ARTHRITIS [PDF]

, 1957
E. C. Franklin, Halsted R. Holman, Hans J. Müller‐Eberhard, Henry G. Kunkel   +3 more
openalex   +1 more source

Development of thermally stable phosphonitrile elastomers for advanced aerospace structures [PDF]

Both high and low molecular weight, curable poly(fluoroalkoxy phosphazene) terpolymers were prepared. These terpolymers resulted from reaction of (Cl2PNn) polymer with alkoxides derived from CF3CH2OH and C3F7CH2OH, and an alkoxide derived from CH3CH(OH ...
Gerber, A. H., Peterson, T., Reynard, K. A., Rose, S. H.   +3 more
core   +1 more source

Discovery and characterizatopn of small molecular weight metallocarboxypeptidase inhibitors [PDF]

, 2010
Descripció del recurs: el 02 de novembre de 2010Las hidrolasas son enzimas que catalizan la ruptura del enlace amida o peptódico, y por lo tanto son denominadas también proteasas o peptidasas. Las proteasas constituyen cerca del 2 % del genoma humano, lo
Avilés, Francesc X., Fernández Fleischhauer, Daniel, Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular   +2 more
core   +1 more source