Results 141 to 150 of about 1,662,372 (302)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Optimization of Preparation Process of Antioxidant Peptides from Golden Pompano (Trachinotus ovatus) Skin by Response Surface Method and Its Composition Analysis

open access: yesShipin gongye ke-ji
In order to promote the comprehensive utilization of the resource of golden pompano skin, this study investigated the optimal preparation process of its antioxidant peptides using golden pompano skin as raw material.
Ziying SU   +6 more
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

Preparation Process Optimization and Physicochemical Properties Characterization of Jinhua Ham Enzymolysis Peptide

open access: yesShipin gongye ke-ji
To investigate the potential of enzymatic hydrolysis for enhancing the nutritional and functional properties of Jinhua ham, a concentrated extract produced by dialysis desalination was employed as a substrate.
Weiqiang WANG   +4 more
doaj   +1 more source

Sensory profile, functional properties and molecular weight distribution of fermented pea protein isolate. [PDF]

open access: yesCurr Res Food Sci, 2021
García Arteaga V   +4 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Computer modeling of the synthesis of styrene–butadiene rubber: Influence of the feed of a chain transfer agent on the characteristics of the product

open access: yesТонкие химические технологии
Objectives. To develop mathematical approaches and algorithms for analyzing the influence of various methods for feeding a chain transfer agent to a cascade of reactors, taking into account the choice of feed points on the characteristics of the final ...
T. A. Mikhailova, S. A. Mustafina
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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