Results 121 to 130 of about 5,323,640 (377)

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Effect of ECAP and volume ultrasonic treatment on the corrosion resistance of magnesium [PDF]

open access: yesBIO Web of Conferences
Magnesium and its alloys are promising materials for manufacturing bioresorbable implants. Various combinations of thermo-mechanical processing are used to improve the mechanical properties and corrosion resistance of magnesium alloys, forming the ...
Aksenov Denis   +4 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Dynamical Casimir-Polder interaction between a chiral molecule and a surface

open access: yes, 2015
We develop a dynamical approach to study the Casimir-Polder force between a initially bare molecule and a magnetodielectric body at finite temperature.
Barcellona, Pablo   +3 more
core   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88

open access: yesBMC Biology, 2018
Background Higher-order self-assembly of proteins, or “prion-like” polymerisation, is now emerging as a simple and robust mechanism for signal amplification, in particular within the innate immune system, where the recognition of pathogens or danger ...
Ailís O’Carroll   +11 more
doaj   +1 more source

Slow Vibrations in Transport through Molecules

open access: yes, 2005
We show how one can measure the signal from slow jumps of a single molecule between metastable positions using a setup where the molecule is fixed to one lead, and one of the coupling strengths is controlled externally.
Belzig, Wolfgang, Heikkila, Tero T.
core   +1 more source

The Constitution of Molecules [PDF]

open access: yesNature, 1921
THE remarks attributed to me in NATURE of October 13 (p. 219) give an incorrect impression of what I intended to convey to the meeting. The statement that the molecular heats “are inconsistent with the arrangement which has been adopted to account for chemical valency” was not made.
openaire   +2 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Kondo effect in oscillating molecules

open access: yes, 2009
We consider electronic transport through break-junctions bridged by a single molecule in the Kondo regime. We describe the system by a two-channel Anderson model. We take the tunneling matrix elements to depend on the position of the molecule.
Al-Hassanieh   +27 more
core   +1 more source

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