Results 161 to 170 of about 3,473,423 (297)

Electrically tuned hyperfine spectrum in neutral Tb(ii)(Cp^iPr5)₂ single-molecule magnet [PDF]

, 2020
Robert L. Smith, Aleksander L. Wysocki, Kyungwha Park, Robert L. Smith, Aleksander L. Wysocki, Kyungwha Park   +5 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Direct microsecond wide-field single-molecule tracking and super-resolution mapping via CCD vertical shift. [PDF]

Nat Commun
Steves MA, Xu K.
europepmc   +1 more source

High Concentration of Antioxidants N-Acetylcysteine and Mitoquinone-Q Induces Intercellular Adhesion Molecule 1 and Oxidative Stress by Increasing Intracellular Glutathione [PDF]

, 2007
Tapan K. Mukherjee, Anurag Mishra, Srirupa Mukhopadhyay, John R. Hoidal   +3 more
openalex   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, Volume 19, Issue 12, Page 3651-3664, December 2025.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Effect of hydrogen migration on the electronic structure of phenol derivatives observed by single-molecule conductance. [PDF]

Nat Commun
Wei X, Li M, Chang X, Song Z, Duan P, Jia C, Guo X.   +6 more
europepmc   +1 more source

Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)

, 2017
Donald Pinto, Michael J. Orwat, Leon M. Smith, Mimi L. Quan, Patrick Y. S. Lam, Karen A. Rossi, Atsu Apedo, Jeffrey M. Bozarth, Yiming Wu, Joanna J. Zheng, Baomin Xin, Nathalie Toussaint, Paul Stetsko, Olafur Gudmundsson, Brad D. Maxwell, Earl J. Crain, Pancras C. Wong, Zhen Lou, Timothy W. Harper, Silvi A. Chacko, Joseph E. Myers, S. Sheriff, Huiping Zhang, Xiaoping Hou, Arvind Mathur, Dietmar Seiffert, Ruth R. Wexler, Joseph M. Luettgen, William R. Ewing   +28 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Modeling molecular environment of allomorphic N-salicylidene-4-halo-aniline crystals through iterative QM/QM' structural optimization. [PDF]

J Mol Model
Xu M, Suzuki M, Koibuchi R, Yoshikawa I, Houjou H.   +4 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source