Results 61 to 70 of about 3,138,502 (297)

Single-molecule pulling: phenomenology and interpretation

, 2013
Single-molecule pulling techniques have emerged as versatile tools for probing the noncovalent forces holding together the secondary and tertiary structure of macromolecules. They also constitute a way to study at the single-molecule level processes that
Allinger, Ashkin, Basu, Berendsen, Bustamante, Camden, Chodera, Crooks, Evans, Ferrenberg, Franco, Franco, Franco, Frenkel, Freund, Gebhardt, Gunari, Halperin, Harris, Harvey, Hess, Heymann, Hoover, Hub, Huguet, Hummer, Hummer, Hummer, Imparato, Isralewitz, Izrailev, Jarzynski, Jarzynski, Jarzynski, Jarzynski, Kim, Kirkwood, Kirmizialtin, Kreuzer, Kubo, Kumar, Lee, Liphardt, Liphardt, Marsili, Martyna, McCullagh, Minh, Moerner, Neuman, Newman, Nitzan, Nosé, Oberhauser, Park, Phillips, Pohorille, Rief, Ritort, Roux, Rubinstein, Schäfer, Strick, Süzen, Thijssen, Weiss   +65 more
core   +1 more source

The Area Law of Molecular Entropy: Moving beyond Harmonic Approximation

Entropy
This article shows that the gas-phase entropy of molecules is proportional to the area of the molecules, with corrections for the different curvatures of the molecular surface.
Amitava Roy, Tibra Ali, Vishwesh Venkatraman   +2 more
doaj   +1 more source

Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators

Frontiers in Nutrition, 2019
Unmethylated cytosine–guanine dinucleotide (CpG) motifs are potent stimulators of the host immune response. Cellular recognition of CpG motifs occurs via Toll-like receptor 9 (TLR9), which normally activates immune responses to pathogen-associated ...
Shireen Nigar, Takeshi Shimosato
doaj   +1 more source

Thermopower of Single-Molecule Devices

, 2004
We investigate the thermopower of single molecules weakly coupled to metallic leads. We model the molecule in terms of the relevant electronic orbitals coupled to phonons corresponding to both internal vibrations and to oscillations of the molecule as a ...
D. V. Averin, Eran Sela, Felix von Oppen, G. D. Mahan, J. Park, Jens Koch, K. Blum, M. A. Reed, Yuval Oreg   +8 more
core   +1 more source

Monomeric PcrA helicase processively unwinds plasmid lengths of DNA in the presence of the initiator protein RepD [PDF]

, 2013
The helicase PcrA unwinds DNA during asymmetric replication of plasmids, acting with an initiator protein, in our case RepD. Detailed kinetics of PcrA activity were measured using bulk solution and a single-molecule imaging technique to investigate the ...
Arbore, Arthur, Atkinson, Bird, Brune, Byrd, Byrd, Chao, Cheng, Christopher P. Toseland, Corrie, Dillingham, Dillingham, Dillingham, Dillingham, Dillingham, Fili, Fili, Gorbalenya, Greenstein, Gregory I. Mashanov, Iordanescu, Justin E. Molloy, Kunzelmann, Leatherbarrow, Lee, Levin, Liisa T. Chisty, Lohman, Lohman, Manosas, Mark S. Dillingham, Martin R. Webb, Mashanov, Natalia Fili, Niedziela-Majka, Noirot, Sellers, Singleton, Slatter, Soultanas, Soultanas, Soultanas, Subramanya, Thomas, Thomas, Toseland, Veaute, Velankar, Webb, Yamaguchi, Yang, Yarranton, Yeeles, Zhang   +54 more
core   +1 more source

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

Research Advances in Molecular Regulatory Mechanism of Chordoma

Zhongliu Fangzhi Yanjiu, 2019
Chordoma is a rare primary malignant bone tumor derived from notochord remnants. Due to its strong local invasiveness and chemotherapy resistance, chordoma has a high local recurrence rate and poor prognosis.
LIANG Chen, YANG Chenlong, LIU Xiaoguang
doaj   +1 more source

Single-Molecule Enzymology [PDF]

Journal of Biological Chemistry, 1999
Viewing a movie of an enzyme molecule made by molecular dynamics simulation, we see incredible details of molecular motions, be they changes of the conformation or actions during a chemical reaction. Molecular dynamics simulations have advanced our understanding of the dynamics of macromolecules in ways that would not be deducible from the static ...
X S, Xie, H P, Lu
openaire   +2 more sources

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Drug selection for inner ear therapy

Frontiers in Pharmacology
IntroductionOne of the primary tenets in pharmacotherapy is that the applied drug must reach the target tissue at therapeutic concentration. For many therapies intended to treat hearing disorders it has become apparent that we have failed to achieve this
Alec N. Salt, Jeremy G. Turner
doaj   +1 more source