Results 81 to 90 of about 2,067,232 (315)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Discovery of a Small-Molecule-Dependent Photolytic Peptide
, 2020 We accidentally found that YM-53601, a known small-molecule inhibitor of squalene synthase (SQS), selectively depletes SQS from mammalian cells upon UV irradiation.
Louvy Lynn Punzalan (8269551) +5 more
core +1 more source
Single-Molecule-Based Electroluminescent Device as Future White Light Source
, 2019 During the last two decades, spectacular development of light-emitting diodes (LEDs) has been achieved owing to their widespread application possibilities.
Shie-Ming Peng (1425703) +8 more
core +2 more sources
Nature Chemistry, 2013 A collection of articles in this issue focuses on the chemical origin of life — how simple molecules present on the early Earth could have evolved into the complex dynamic biochemistry that we know today.
openaire +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Molecule-Based Materials: The Structural Network Approach
, 2005 The properties of a material depend not only on the specific atoms and molecules it contains, but also on the arrangement of these in space. Many of these three-dimensional arrangements are described as "3D-nets" or "3D-networks".
Larsson, K. +5 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
, 2013 Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing beta-cells in the pancreas. Recruitment of inflammatory cells is prerequisite to beta-cell-injury.
Imhof, Beat A. +24 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Versatile Control System for Automated Single-Molecule Optical Tweezers Investigations
, 2010 We present a versatile control system to automate single-molecule biophysics experiments. This method combines low-level controls into various functional, user-configurable modules, which can be scripted in a domain-specific instruction language.
Steven J. Koch, Richard C. Yeh
core