Results 61 to 70 of about 2,242,520 (263)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Research Advances in Molecular Regulatory Mechanism of Chordoma
Zhongliu Fangzhi Yanjiu, 2019 Chordoma is a rare primary malignant bone tumor derived from notochord remnants. Due to its strong local invasiveness and chemotherapy resistance, chordoma has a high local recurrence rate and poor prognosis.
LIANG Chen, YANG Chenlong, LIU Xiaoguang
doaj +1 more source
The Expression of Myoz1 and ApoB is Positively Correlated with Meat Quality of Broiler Chicken
Veterinary Medicine International, 2022 Broiler chicken (Gallus gallus) is a source of animal protein with a high nutritional content. The purpose of this study was to evaluate the quality of broiler chicken meat (Gallus gallus) by analyzing its nutritional value, genetic profile, and protein ...
Fatchiyah Fatchiyah +7 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Planta Daninha, 2006 Este trabalho teve por objetivo estabelecer as variações na atividade alelopática da substância química titonina, em função da acetilação de sua molécula.
A.P.S. Souza Filho +2 more
doaj +1 more source
Artificial Nonlinearity Generated from Electromagnetic Coupling Meta-molecule
, 2018 A purely artificial mechanism for optical nonlinearity is proposed based on a metamaterial route. The mechanism is derived from classical electromagnetic interaction in a meta-molecule consisting of a cut-wire meta-atom nested within a split-ring meta ...
Yongzheng Wen (5937644) +1 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Drug selection for inner ear therapy
Frontiers in PharmacologyIntroductionOne of the primary tenets in pharmacotherapy is that the applied drug must reach the target tissue at therapeutic concentration. For many therapies intended to treat hearing disorders it has become apparent that we have failed to achieve this
Alec N. Salt, Jeremy G. Turner
doaj +1 more source
Design of single-molecule optical devices : unidirectional photonic wires and digital photoswitches [PDF]
, 2005 Heilemann M. Design of single-molecule optical devices : unidirectional photonic wires and digital photoswitches. Bielefeld (Germany): Bielefeld University; 2005.Molecular photonics is a new emerging field of research around the premise that it is ...
Heilemann, Mike
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source