Results 71 to 80 of about 5,095,036 (399)
Studies in History and Philosophy of Science Part A, 2011 Recent philosophy of science has seen a number of attempts to understand scientific models by looking to theories of fiction. In previous work, I have offered an account of models that draws on Kendall Walton's 'make-believe' theory of art. According to this account, models function as 'props' in games of make-believe, like children's dolls or toy ...
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Cell, 2009 My professional life over five decades meandered from a high school ambition to be a psychiatrist and understand the "mind" to biochemical studies of neurotransmitters and drugs. Hopefully, the tale of my quirky impatient curiosity about "too many" different areas will be useful for young scientists embarking on their own careers.
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FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Single-molecule Electronics: Cooling Individual Vibrational Modes by the Tunneling Current
, 2015 Electronic devices composed of single molecules constitute the ultimate limit in the continued downscaling of electronic components. A key challenge for single-molecule electronics is to control the temperature of these junctions. Controlling heating and
Gagliardi, Alessio +4 more
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From molecules in space to molecules in breath [PDF]
Paediatric Respiratory Reviews, 2016 The evolution of the selected ion flow tube, SIFT, used to study ion-molecule reactions of interstellar significance, to the selected ion flow tube mass spectrometry, SIFT-MS, analytical technique is described briefly. Focus is placed on the application of SIFT-MS to breath analysis and its potential for the detection of volatile biomarkers of disease ...
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FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Driving current through single organic molecules [PDF]
Phys. Rev. Lett. 88, 176804 (2002), 2001 We investigate electronic transport through two types of conjugated molecules. Mechanically controlled break-junctions are used to couple thiol endgroups of single molecules to two gold electrodes. Current-voltage characteristics (IVs) of the metal-molecule-metal system are observed.
arxiv +1 more source
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
Science, 2016 Powering down yields a healthier heart In hypertrophic cardiomyopathy (HCM), the heart muscle enlarges and becomes progressively less efficient at pumping blood. HCM can be caused by mutations in components of the sarcomere (the heart's contractile unit),
Eric M. Green +18 more
semanticscholar +1 more source
Rotational States of Magnetic Molecules
, 2009 We study a magnetic molecule that exhibits spin tunneling and is free to rotate about its anisotropy axis. Exact low-energy eigenstates of the molecule that are superpositions of spin and rotational states are obtained. We show that parameter $\alpha = 2(
A. R. Edmonds +5 more
core +2 more sources
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source