Results 131 to 140 of about 4,790,746 (299)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The role of interleukin‐22 in mammalian intestinal homeostasis: Friend and foe
Immunity, Inflammation and DiseaseInterleukin‐22 (IL‐22) is an important cytokine in the intestinal environment. IL‐22 is mainly produced by immune cells and targeted at nonimmune cells such as epithelial and stromal cells in a broad array of tissues such as ‐but not restricted to‐ the ...
Hedi‐Britt Klotskova +3 more
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Chemical Synthesis in the Circumstellar Environment
GalaxiesWe discuss the spectral distinctions between B[e] stars and compact planetary nebulae. The differentiation between proto-planetary nebulae, transition objects between the asymptotic giant branch and planetary nebulae, and reflection nebulae in binary ...
Sun Kwok
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Studies in History and Philosophy of Science Part A, 2011 Recent philosophy of science has seen a number of attempts to understand scientific models by looking to theories of fiction. In previous work, I have offered an account of models that draws on Kendall Walton's 'make-believe' theory of art. According to this account, models function as 'props' in games of make-believe, like children's dolls or toy ...
openaire +3 more sources
Synthesis of Organic and Inorganic Compounds in Asymptotic Giant Branch Stars
GalaxiesAfter the synthesis of carbon in the core of asymptotic giant branch (AGB) stars, carbon is dredged up to the surface by convection. Many carbon-based molecules are formed in the subsequently developed stellar wind.
Sun Kwok
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
From Molecules to Minds: Toward a Multiscale Paradigm in Translational Medicine [PDF]
Journal of Advanced Biomedical SciencesTranslational medicine has long aspired to create a seamless continuum from molecular discovery to clinical application. Yet, despite technological advances, progress remains hindered by disciplinary silos.
Ali Taghinezhad
doaj
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source