Results 141 to 150 of about 3,169,273 (304)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The role of interleukin‐22 in mammalian intestinal homeostasis: Friend and foe
Immunity, Inflammation and DiseaseInterleukin‐22 (IL‐22) is an important cytokine in the intestinal environment. IL‐22 is mainly produced by immune cells and targeted at nonimmune cells such as epithelial and stromal cells in a broad array of tissues such as ‐but not restricted to‐ the ...
Hedi‐Britt Klotskova +3 more
doaj +1 more source
All-optical reconfigurable chiral meta-molecules
, 2019 Chirality is a ubiquitous phenomenon in the natural world. Many biomolecules without inversion symmetry such as amino acids and sugars are chiral molecules.
Linhan Lin (1440487) +7 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Chemical Synthesis in the Circumstellar Environment
GalaxiesWe discuss the spectral distinctions between B[e] stars and compact planetary nebulae. The differentiation between proto-planetary nebulae, transition objects between the asymptotic giant branch and planetary nebulae, and reflection nebulae in binary ...
Sun Kwok
doaj +1 more source
Adhesion molecules in dementia
, 2016 During the past decade it has become evident that immunological, infl ammatory and vascular processes play an important role in the etiology and pathogenesis of various neuro-degenerative diseases.
Jianping, Jia, +3 more
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Synthesis of Organic and Inorganic Compounds in Asymptotic Giant Branch Stars
GalaxiesAfter the synthesis of carbon in the core of asymptotic giant branch (AGB) stars, carbon is dredged up to the surface by convection. Many carbon-based molecules are formed in the subsequently developed stellar wind.
Sun Kwok
doaj +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
From Molecules to Minds: Toward a Multiscale Paradigm in Translational Medicine [PDF]
Journal of Advanced Biomedical SciencesTranslational medicine has long aspired to create a seamless continuum from molecular discovery to clinical application. Yet, despite technological advances, progress remains hindered by disciplinary silos.
Ali Taghinezhad
doaj