Results 61 to 70 of about 140,903 (252)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Formation and analysis of pore defects in TC4 alloy by SLM printed
Cailiao gongchengThis study investigates the characteristics and formation mechanisms of pore defects in TC4 titanium alloy fabricated via selective laser melting （SLM） through numerical simulation and industrial computed tomography （CT） analysis.
WANG Chunjin +3 more
doaj +1 more source
Electrochemical Separation of Molybdenum and Tungsten Using Aqueous-Organic Electrolytes
Eurasian Chemico-Technological Journal, 2020 Molybdenum is one of the valuable metals for the industry; its special properties make it extremely urgent to study the process of separation of molybdenum from other impurities.
L. K. Kudreeva +7 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Assessment of reheat cracking susceptibility in chromium-molybdenum-vanadium turbine rotor steel.
, 1990 Assessment of reheat cracking susceptibility in chromium-molybdenum-vanadium turbine rotor ...
Gwangsoo. Kim (7957742)
core +2 more sources
Applied SciencesDuring the molybdenite mining process, conveyor belts stretching for miles are used to transport ore between the blasting sites, crushing stations, and the concentrator plant.
Meng Li +4 more
doaj +1 more source
View, 2021 Molybdenum (Mo), as a nontoxic and low‐cost transition metal, has been employed for synthesis of various Mo‐based nanomaterials with unique structures and physicochemical features to achieve various properties.
Yan Zu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source