Results 71 to 80 of about 140,903 (252)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
, 2023 The first molybdenum-catalyzed highly regio- and enantioselective allylic amination of both aryl- and alkyl-substituted branched allylic carbonates has been developed.
Junjie Zhang (355622) +2 more
core +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Serum Concentration of Molybdenum in Chronic Renal Failure Patients Requiring Hemodialysis
مجلة كلية الطب, 2012 Background: High serum molybdenum level may contribute to dialysis related bone disease in patients requiring long term hemodialysis in fact massive molybdenum accumulation causes joint deformity and arthritis Objective: To asses the level of molybdenum ...
Jawad K. Manuti +2 more
doaj +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Computational Studies of Molybdenum and Tungsten Enzymes
, 2016 We review computational studies of three important mono-nuclear molybdenum oxo-transfer enzymes, dimethylsulfoxide reductase, sulfite oxidase and xanthine oxidase.
Mata, Ricardo A. +17 more
core +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Molybdenum Tris(2,5-dimethylpyrrolide), a Rare Homoleptic Molybdenum(III) Monomer
, 2016 The monomeric, homoleptic molybdenum(III) complex molybdenum tris(2,5-dimethylpyrrolide) has been prepared. Reduction with KC8 in THF yields the molybdenum(II) complex potassium [molybdenum tris(2,5-dimethylpyrrolide)], while protonation with [H(OEt2)2 ...
Richard R. Schrock (1295601) +1 more
core +2 more sources
Scientific Papers Animal Science and Biotechnologies, 2023 The aim of this study was to test the pea plant as sentinel specie for the heavy metal molybdenum. Evaluation of soil quality after the molybdenum uptake by pea revealed the following results: Pea plant is a bioindicator that concentrates molybdenum with
MONICA BUTNARIU +2 more
doaj