Results 91 to 100 of about 386,582 (351)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Microwave energy attenuators of high thermal conductivity based on AlN and SiC with addition of molybdenum [PDF]

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2014
The paper presents the results of experimental studies of thermal conductivity and microwave absorption in aluminum nitride based composites with different percentages of silicium carbide and molybdenum.
Chasnyk V. I., Fesenko I. P.
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Exogenous application of molybdenum affects the expression of CBF14 and the development of frost tolerance in wheat. [PDF]

, 2013
Wheat is able to cold acclimate in response to low temperatures and thereby increase its frost tolerance and the extent of this acclimation is greater in winter genotypes compared to spring genotypes.
Al-Issawi, M, Burchett, S, Fuller, MP, Rihan, HZ, Woldie, WA   +4 more
core   +2 more sources

Molybdenum and tungsten manufactured by selective laser melting: Analysis of defect structure and solidification mechanisms

International Journal of Refractory Metals and Hard Materials, 2019
In this work, processing of molybdenum and tungsten by Selective Laser Melting (SLM) is analyzed. The study reveals the impact of the oxygen content of the powder, the process atmosphere and the temperature of the substrate plate on the structural and ...
J. Braun, L. Kaserer, J. Stajkovic, K. Leitz, B. Tabernig, P. Singer, P. Leibenguth, C. Gspan, H. Kestler, G. Leichtfried   +9 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Ultrafast and spatially resolved studies of charge carriers in atomically-thin molybdenum disulfide

, 2012
Atomically-thin molybdenum disulfide is emerging as a new nanomaterial with potential applications in the fields of electronic and photonics. Charge carrier dynamics plays an essential role in determining its electronic and optical properties.
Bellus, Matthew Z., Chiu, Hsin-Ying, Kumar, Nardeep, Ruzicka, Brian A., Wang, Rui, Zhao, Hui   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Serum Concentration of Molybdenum in Chronic Renal Failure Patients Requiring Hemodialysis

مجلة كلية الطب, 2012
Background: High serum molybdenum level may contribute to dialysis related bone disease in patients requiring long term hemodialysis in fact massive molybdenum accumulation causes joint deformity and arthritis Objective: To asses the level of molybdenum ...
Jawad K. Manuti, Faisal Gh. Al-Rubaye, Mahmood S. Khudhair   +2 more
doaj   +1 more source