Results 21 to 30 of about 95,145 (229)
Inorganics, 2020 Iron-sulfur (Fe-S) clusters are essential protein cofactors. In enzymes, they are present either in the rhombic [2Fe-2S] or the cubic [4Fe-4S] form, where they are involved in catalysis and electron transfer and in the biosynthesis of metal-containing ...
Ralf R. Mendel +4 more
doaj +1 more source
Incorporation of Molybdenum into the Iron-Molybdenum Cofactor of Nitrogenase [PDF]
Journal of Biological Chemistry, 1999 The biosynthesis of the iron-molybdenum cofactor (FeMo-co) of dinitrogenase was investigated using 99Mo to follow the incorporation of Mo into precursors. 99Mo label accumulates on dinitrogenase only when all known components of the FeMo-co synthesis system, NifH, NifNE, NifB-cofactor, homocitrate, MgATP, and reductant, are present.
R M, Allen +5 more
openaire +2 more sources
Biology, 2023 Cobalt (Co), copper (Cu), manganese (Mn), molybdenum (Mo), and zinc (Zn) are essential trace elements (ETEs) and important cofactors for intermediary metabolism or redox balance.
Isabella Bracchi +21 more
doaj +1 more source
Discriminating Susceptibility of Xanthine Oxidoreductase Family to Metals
Microbiology Spectrum, 2023 The xanthine oxidoreductase (XOR) family are metal-containing enzymes that use the molybdenum cofactor (Moco), 2Fe-2S clusters, and flavin adenine dinucleotide (FAD) for their catalytic activity.
Anne-Soisig Steunou +7 more
doaj +1 more source
Journal of Biological Chemistry, 2013 The transition element molybdenum needs to be complexed by a special cofactor to gain catalytic activity. Molybdenum is bound to a unique pterin, thus forming the molybdenum cofactor (Moco), which, in different variants, is the active compound at the catalytic site of all molybdenum-containing enzymes in nature, except bacterial molybdenum nitrogenase.
openaire +2 more sources
Molybdenum Cofactor Deficiency in Humans
Molecules, 2022 Molybdenum cofactor (Moco) deficiency (MoCD) is characterized by neonatal-onset myoclonic epileptic encephalopathy and dystonia with cerebral MRI changes similar to hypoxic–ischemic lesions. The molecular cause of the disease is the loss of sulfite oxidase (SOX) activity, one of four Moco-dependent enzymes in men.
Lena Johannes +2 more
openaire +3 more sources
mBio, 2022 Engineering plants to synthesize nitrogenase and assimilate atmospheric N2 will reduce crop dependency on industrial N fertilizers. This technology can be achieved by expressing prokaryotic nitrogen fixation gene products for the assembly of a functional
Xi Jiang +8 more
doaj +1 more source
Biology of the molybdenum cofactor [PDF]
Journal of Experimental Botany, 2007 The transition element molybdenum (Mo) is an essential micronutrient for plants where it is needed as a catalytically active metal during enzyme catalysis. Four plant enzymes depend on molybdenum: nitrate reductase, sulphite oxidase, xanthine dehydrogenase, and aldehyde oxidase.
openaire +2 more sources
Molybdoenzymes and molybdenum cofactor in plants [PDF]
Journal of Experimental Botany, 2002 The transition element molybdenum (Mo) is essential for (nearly) all organisms and occurs in more than 40 enzymes catalysing diverse redox reactions, however, only four of them have been found in plants. (1) Nitrate reductase catalyses the key step in inorganic nitrogen assimilation, (2) aldehyde oxidase(s) have been shown to catalyse the last step in ...
Ralf R, Mendel, Robert, Hänsch
openaire +2 more sources
A crystallographic view of the molybdenum cofactor † [PDF]
Journal of the Chemical Society, Dalton Transactions, 1997 The molybdenum cofactor (Moco) has been found to be associated with a diverse set of redox enzymes and contains a mononuclear molybdenum or tungsten ion co-ordinated by the dithiolene sulfurs of one or two molybdopterin {a pterin [2-amino-4(1H)-pteridinone] derivative} ligands.
Rees, Douglas C. +3 more
openaire +2 more sources